1.00E+03
Power as Func:on of Body Weight on logarithmic scale
1.00E+02
Log(Power (wa+s)
1.00E+01
0.0001
Dobson
1.00E+00
0.001
0.01
0.1
1
10
100
1000
10000
100000
Popovic
1.00E-01
Power
(Dobson)
y = 0.0497x0.8096
R = 1
Species
Maximum
lifespan
(years)
Shrew
Mouse
Rat
Human
Elephant
Blue whale
Mean
1
2
5
80
62
118
Maximum heart
beats
(beats/lifetime)
range
(11.5)
(1.33)
(25)
(28)
6.57E+08
6.62E+08
9.20E+08
3.30E+09
9.87E+08
3.72E+09
1.10E+09
The data is taken from Dobson
1.
Figure 1 shows the intracellular calcium concentration and transmembrane voltage versus
time.
Figure 1. Output of Hund-Rudy model with normal parameters
Vrest was calculated to be -85.8 mV, Vmax was 37.9 mV, dV/dtmax was 272 mV/ms, and
[Ca2+]i,max was
HW # 6
1. Sinus Rhythm
1.1. The depolarization starts in the SA node. Once the Sinus node has stimulated the atrial
myocytes, the intermodal pathways lead the conduction to the AV node. The AV node
leads to the bundle of His in the septum and the bundle o
Alex Yang
396254
April 29, 2010
Homework 6
Sinus Node
1.1 Electrical activity (equivalent to depolarization in our case) originates in the
sinoatrial (SA) node located in the right atrium, which depolarizes the atria while
propagating through Bachmanns Bu
% script to solve and plot ODE in MATLAB
% written by R Okamoto
% define anonymous function
f = 3; A = 1; B=10; 0efine constants FIRST
myfun = @(t,x) t/A*(sin(2*pi*f*t).*(sin(2*pi*f*t)>0)-B*x);
% solve ODE
[t,x]=ode15s(myfun,0:0.001:2,0); % use ode solver
Table 1. Basic morphometric and echocardiography data of different species
Body weight
RR interval
ET
EDV
(kg)
(ms)
(ms)
(ml)
Mouse
(n = 10)
0.028
92.3
42
Rat
(n=15)
0.272
143.9
63
Rabbit
(n=6)
3.01
307.2
125
Dog
(n=8)
26.6
504
166
Human
(n=38)
70.2
938.8