HEMATOLOGY #11 -
MICROCYTIC, HYPOCHROMIC ANEMIA I
Causes: maturational defect resulting in smaller than normal size (MCV<85 fl) and lower than
normal [Hb] (MCHC<30 g/dl).
A. Microcytosis due to extra cell division caused by hypchromia mitosis continues
un
HEMATOLOGY #6 -Erythrocyte:Structure/Composition/Function
I. Erythrocyte Primary Function - Maintenance of Respiration
A. Respiration: utilizes oxygen, releases CO2 , H+
1. Transport of O2 from lung alveoli for delivery to tissue
2. Transport of CO2 from
HEMATOLOGY #7 - HEMOGLOBIN - STRUCTURE & FUNCTION
I.
General Description
Hemo - greek = blood
globin - protein of the hemo/myo globin family
Hemoglobin has two key structures:
1. Heme - prosthetic group; non-protein portion contains Fe
2. Apoprotein(globi
HEMATOLOGY #5 - Erythrocyte Development
Erythron - The complete collection of erythrocyte progenitor, immature, mature and senescing red cells
A. Earliest erythroid precursors - small % of marrow, large nucleoli, many polyribosomes, lg mitochrond,
not dis
HEMATOLOGY#2 - CELLULAR COMPONENTS OF BLOOD
I. Formed Or Particulate Elements of Blood
A.
Examination requires anticoagulants
1.
Coagulation system interacts with foreign surfaces to activate formation of clots which
traps the cellular constitutent in mat
HEMATOLOGY#3 - Hematopoietic Organs and Progenitors
Definition: Hematopoiesis (hemopoiesis) is the process by which pluripotent stem cells mature into
functional mature blood cells
I. HEMATOPOIETIC TISSUE DEVELOPMENT
A. Mesoblastic phase
1. 2-3 weeks afte
HEMATOLOGY #8 INTRO TO ANEMIAS
I.
II.
Anemia Introduction
A. Definition -A clinical condition associated with a decrease in RBC# or Hemoglobin
concentration ([Hb]) or hematocrit
1. Normal RBC # 4.5-5.9 X106 male ; 4.1-5.1 female
2. [Hb] 14.0-17.5 male; 12
HEMATOLOGY #9 NORMOCHROMIC NORMOCYTIC ANEMIAS
I.
Definition: Normochromic/Normocytic Anemia
A. MCV (85-100fl) & MCHC(30-35pg) do not deviate from normal; reticulocytes <4%
B. Most from hypoproliferative bone marrow
C. Relatively common
D. Treatable
II. Ac
HEMATOLOGY# 14 - Hemolytic Anemias I
Erythrocyte Membrane Disorders
I. Fluid mosaic model
A. fluid: lipids & proteins move in plane of membrane bilayer
B. mosaic: membrane composed of protein and lipid
1. phospholipid bilayer
Phospholipids: PE,PC, PI
Chol
HEMATOLOGY# 15 - Hemolytic Anemias II
HEMOGLOBIN DEFECTS -SICKLE CELL ANEMIA/OTHER HEMAGLOBINOPATHIES
I.
Introduction
A. Genetic control of hemoglobin synthesis
1. synthesis of -like,-like globin chains controlled by separate structural genes
a. and genes
HEMATOLOGY #13 - MICROCYTIC, HYPOCHROMIC ANEMIA Part III
I.
Microcytic Hypochromic Anemia
A. Fe deficiencies
B. Heme deficiencies
C. Globin deficiencies Thalassemia
Expression of Hb should be simple, i.e. gene messenger protein
However many Hb occur espec
HEMATOLOGY #12 - MICROCYTIC, HYPOCHROMIC ANEMIA Part II
I.
Abnormalitic in Heme synthesis
A. Sideroblastic Anemia Defective Heme Synthesis
1. Fe incorp normal, Fe can not be bound to a functional protoporphyrin
2. many more hemosiderin particles, Pappenhe
HEMATOLOGY #10 - MEGALOBLASTIC ANEMIA
I.
Definition:
Disorder caused by impaired DNA synthesis and characterized by the presence
of hallmark megaloblastic cells (megaloblasts Megacytic erythrocytes)
II.
Characteristics:
A. Megalobastic precursors > in # t
HEMATOLOGY # 1 -The Study of the Structure and Function of Blood in Health and DiseaseWhy study blood?
Easy to obtain samples repetitively with minimal perturbation of organism;
Provides living tissue with long survival time;
Diversity of cell types with
