Notes Pharmacology 1 Modes of Action
Modes of Action
A compound that does the job of a natural substance.
Does not effect the rate of an enzyme catalyzed reaction.
Tolerance/sensitivity at the cellular level may be due to a
Pharm 2 Exam 1 Study Guide
Hypnotic drugs- drugs that help you fall asleep
Sedative-hypnotic drugs: depress CNS function, used to treat anxiety and
insomnia, antianxiety agents or anxiolytics.
Other CNS depressants: opioid, antihistamine, alcohol
PHARMACOLOGY STUGY GUIDE
Pharmacology & the Role of the Nurse
Pharmacodynamics: what substances do to the body
Pharmacokinetics: what the body does to the drug (drug movement through the body)
FDA Approved Drugs VS Dietary Supplements
Rights of Medication
Notes Pharmacology 1 Toxicology
Study of poisonous effect or toxicity of drugs
Toxic effects includes:
Adverse effect on a fetus or infant
Adverse reactions reported in clinical trials
Adverse effect in pediatric or elderly patients
Notes Pharmacology 1 Potency
Relative strength of response for a given dose
Effective concentration (EC50) is the concentration of an agonist needed to
elicit half of the maximum biological response of the agonist
The potency of an agonist is i
Notes Pharmacology Misc. Drugs
Common side effects of Selective Serotonin Reuptake Inhibitors (SSRIs) are
o Appetite loss
o weight loss
o sexual dysfunction and deranged liver function tests.
o Similarly, the common side eff
Notes Pharmacology 1 Law of Mass Action Safety and Efficacy
Law of Mass Action
(a model to explain ligand-receptor binding)
When a drug combines with a receptor, it does so at a rate which is dependent
on the concentration of the drug and of the receptor
Notes Pharmacology 1 Introduction
The process by which a drug is absorbed, distributed, metabolized and
eliminated by the body
The interactions of a drug and the receptors responsible for its action in
Notes Pharmacology 1 Absorption
Ionized (have electrical charge)
Crosses through pores in capillaries, but not cell membranes
Non-ionized (no electrical charge)
Crosses pores, cell membranes, b
Notes Pharmacology 1 Effects
The condition in which repeated administration of a drug may produce effects
that are more pronounced than those produced by the first dose.
The effect of two chemicals is equal to the sum
Notes Pharmacology 1 Kinetics
First order kinetics
A constant fraction of drug is eliminated per unit of time.
When drug concentration is high, rate of disappearance is high.
Zero order kinetics
Rate of elimination is constant.
Rate of elimination is