Who am I?
Assistant Professor, Biology & Chemistry
Office: 3-010 CST
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Chapter 36: Drug Development
Drugs take a long time to develop and are very costly
in terms of research and development.
Average cost of getting a new drug approved: $2.6 billion.
1. Drug Rese
V. Diabetes is a disease where the exquisite metabolic control is
thrown into chaos.
Glucose overproduced in liver, and underutilized in other
organs, resulting in grossly abnormal fuel usage.
Affects 5% of population.
Type I no insulin p
Photosynthesis as we know it today
What are some of the differences then?
1 reaction center: P960
Cyclic electron flow
Does not use H2O
Generates only ATP
2 reaction centers: P680/P700
Electron flow is not cyclic
New electrons com
Every time photon ejects an electron from P680, P680 gets
its replacement electron from the manganese center
Mn was evolutionarily chosen, as it can exist in 4 oxidation states (Mn2+, Mn3+, Mn4+, Mn5+)
1st Major point: 4 photons are used to
The 26S proteasome:
the molecular analog of a molecular recycling machine
19S Regulatory Cap
1) binds polyUb chains;
2) cleaves polyUb chains;
3) ATP-mediated conf
change that directs target
Protein turnover and amino acid breakdown
Cyclin B, a cell division regulatory protein
GFP fused to Cyclin B
No)ce the absence!
Amino Acid Sources
(especially those c