Lecture Summary 23 October 18, 2006
Chapter 8 - Alkynes: An Introduction to Organic Synthesis Hydrogenation of Alkynes Catalytic hydrogenation with hydrogen gas using Lindlar's catalyst is specific for generating the cis alkene. Trans alkenes can be prepa
Lecture Summary 27 October 30, 2006
Chapter 10 - Alkyl Halides Preparation of Alkyl Halides - substitution of alcohols The conditions for substitution of an alcohol functional group with a halogen depends on the degree of alkyl substitution on the alchol.
Lecture Summary 31 November 8, 2006
Chapter 11 - Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations Summary of Substitution and Elimination Reactions Sometimes it is difficult to tell what mechanism will be the predominant pathway in
Nuclear Magnetic Resonance
A spinning charged particle generates a magnetic field. A nucleus with a spin angular momentum will generate a magnetic moment ().
If these tiny magnets are placed in an applied magnetic field (B
2006 Nobel Prize in Chemistry
"for his studies of the molecular basis of eukaryotic transcription"
Prof. Roger Kornberg Dept. of Structural Biology Stanford University School of Medicine
Heterocycles in DNA and RNA
NH2 N N H N N N N H N NH2
Quiz 01 - KEY September 13, 2006
3 Points Each. Please mark your answers on the scantron sheet. You may keep this copy. 1. What is the hybridization of the carbon indicated below?
a) not hybridized
2. Which of the following compounds
Quiz 02 October 05, 2006
3 Points Each. Please mark your answers on the scantron sheet. You may keep this copy. 1. Which of the following substituents would have the lowest Cahn-Ingold-Prelog priority
Quiz 05 KEY November 29, 2006
3 Points Each. Please mark your answers on the scantron sheet. You may keep this copy. 1. Molecules absorb infrared radiation at frequencies that relate to . . . ? (a) the number of hydrogens in the molecule (b) the rate of c
Quiz 06 December 04, 2006
3 Points Each. Please mark your answers on the scantron sheet. You may keep this copy. 1. How many different resonances would the following molecule show in the 1H NMR spectrum?
CH3 O CH3 C CH3 C O CH2 CH2 CH3
Organic Synthesis Strategy
The preparation of more complex molecules from
commercially available starting materials via a multistep sequence of transformations.
O O OH HO PhOCO H AcO O
1. Which of the following statements regarding compounds A-C is true?
a. B has the highest boiling point and the lowest water solubility
b. A is highest boiling; B has the lowest water solubility
c. C is highest boili
Quiz 4, Stereochemistry, Chem 341
1. For each structure, a) star any chiral carbons, b) label each chiral carbon as (R) or (S) and c)
indicate any molecules that are chiral. [Two tools for assigning chirality: chiral carbons and
planes of symmetry
1. For the compound methylamine, CH3NH2, which of the following statements is true for the nitrogen atom?
It has a formal +1 charge.
It has a formal -1 charge.
It has no formal charge, but has a slight nega
Lecture Summary 21 October 13, 2006
Chapter 7 - Alkenes: Reactions and Synthesis Oxidation of Alkenes There are several oxidizing agents that will oxidize alkenes to varying levels of oxidation states. The addition of two oxygens to a double bond can be a
Lecture Summary 20 October 11, 2006
Chapter 7 - Alkenes: Reactions and Synthesis Addition of Carbenes The second method utilizes Zn to carry out overall an elimination of I and I from a carbon. Carbenes have dual reactivity and will form two bonds at once
Answers to Additional Problems Chapter 2
Additional Practice Problems Briefly explain why protonated triphenylmethanol would more easily dissociate into the corresponding cation and water than protonated tert-butanol.
CH3 H3C C O CH3
CH 3 H 3C C CH 3
Suggested Problems Chapter 06
Problems from your text 6.3, 6.4, 6.5, 6.7, 6.10, 6.11, 6.14, 6.16, 6.18, 6.19, 6.24, 6.26, 6.29, 6.35, 6.39, 6.41, 6.42, 6.44, 6.49, 6.53
Additional Practice Problems 1. a) In the following reaction of the addition of HCl to
Answers to Additional Problems Chapter 10-11
Additional Practice Problems 1. Which of the following diastereomers would undergo E2 elimination faster. Explain.
Br Br most stable conformation cannot eliminate H H
must be in this conformation with H's
anti Butane Conformations
Butane Conformations H3C H C H HH C CH3
view down this axis to see Newman Projection
H anti-methyls - 180 H
CH3 Newman Projection anti-staggered
eclipsed Butane Conformations
Butane Conformations H H CH3 Newman
Axial and Equatorial Positions of Cyclohexane
Pink - Axial Blue - Equatorial
Cyclohexane Axial Positions More Crowded
1,3-diaxial interaction axial methyl H CH3 ring flip H H H H
equatorial methyl H H H H H CH3
1.8 kcal/mol more stable con
Exam 01 22 September 2006 NAME
Please read through each question carefully and answer in the spaces provided. A good strategy is to go through the test and answer all the questions you can do easily. Then go back and tackle the more difficult problems. Pl
Final Exam 12 December 2006 NAME
Please read through each question carefully and answer in the spaces provided. A good strategy is to go through the test and answer all the questions you can do easily. Then go back and tackle the more difficult problems.
Energy of a photon
Typical IR Spectra
Typical Ranges for common functional groups
wavenumber, cm-1 2500 2000
Lecture Summary 04 August 30, 2006
Chapter 2 - Polar Covalent Bonds; Acids and Bases Formal Charge When atoms have more or less number of bonds than their valency requires, they must have a charge that is not zero. A formal charge is a way of keeping trac
Lecture Summary 05 September 01, 2006
Chapter 2 - Polar Covalent Bonds; Acids and Bases Brnsted-Lowry Acids and Bases Acid base reactions are fundamental processes that are required for the initiation of many organic reactions. Recall some of the definiti
Quiz 3, Radical Halogenation, Chem 341
1. Write the mechanism (propagation steps only!) for the reaction of propane with bromine to give 2bromopropane. Include detailed arrow-pushing.
2. Rank the stability of the following radicals, from 1 (mos