Review Sheet for Exam 1
Basically anything we discussed in lecture or in lab from Monday, January 20 to
Monday, February 17 (or until we finish entry) could be on the exam. Below is a topic
list and some practice questions.
Student Generated Exam Practice Application Questions:
1. A new drug, Halt-a-Virus, has been engineered to degrade capsid proteins VP2 and VP6.
Explain how this method of action would affect the infectivity of Rotavirus.
Answer: Rotavirus is unique in tha
Student Generated Exam Practice Recall Questions:
1. Describe antigenic shift and how it is a virulence factor.
Answer: Antigenic shift involves the recombination of viral genome segments from at least two
different viruses. This is a virulence factor for
Dr. Christine Weingart
April 23, 2014
Viruses in the News Assignment
In Catharine Paddocks article New Target in flu virus may open route to better drugs,
Paddock summarizes the recent work of Robert Krug on the pathogenesis of the
Phage Hunting: Project design and phage collection
(For lab session January 24)
Background: Because of the emergence of antibiotic resistant bacteria, scientists and
physicians fear that we are running out of options to cure diseases caused by pathogenic
Investigation of Effectiveness of Phage Therapy in Alfalfa Model of Pseudomonas aeruginosa
The Department of Biology at Denison University, 100 West College Street, Granville, OH 43023
This study sought to investigate the effectivenes
Due on March 26
1. To analyze data you generated and communicate your findings by writing a
scientific manuscript for the Journal of Virology.
As scientists, it is critical to communica
1. The objective of this exercise is to help you compare and contrast the replication strategies of the viruses we discussed. Be as
specific as you can.
Proteins in the capsid
Type of genome
Polarity of genome
Examination of the effect of bacteriophage on Pseudomonas pathogenesis
(For lab sessions Feb. 21, 28, and March 7)
Background: As you recall we are working to find a bacteriophage specific for P. aeruginosa,
and then determine if it can be used as an effe