7 September 2016
Discussion Questions 2
Distinguish which pathways are considered part of an adaptive immune response and
which are considered part of innate immunity, and explain why.
1. Alternate Pathway innat
Induced innate response includes
1.) Activation of resident cells
2.) Recruitment of effector cells, which generally occurs during inflammation
4.) Acute phase proteins
Macrophage pattern recognition receptors typically fall into
Adaptive immune response is divided into humoral and cellular immunity.
Humoral b-cells, cellular t cells.
B- Cells hit things outside the cell
T- Cells hit things inside the cell
Effector cell in humoral immunity is the plasma cell. It se
Know figure 3.34
Plasmocytoid dendritic cell look like plasma cells produce type 1 interferons (alpha and beta) at 1000
times higher levels than other cells.
They detect the virus infection through toll receptors and prevent the spread of t
Extra Credit Multiple Choice Questions
1. Which of the following apply to innate or nonspecific immune responses?
a. Rapid response (hours)
b. Limited specificity
c. Constant during response
d. All of the above
Extra Credit Exam Questions
1. All of the following are antibody class types except for:
2. Which of the following is not a region located on the typical antibody?
a. a light ch
Extra Credit for Exam 3
1. Which of the following is NOT a similarity between Ab and TCR?
a. Both have variable regions and c regions
b. Both v regions contain the Ag binding site
c. Both have no cytoplasmic do
1/21/15 MWF 9:00-9:50
3703 Discussion Question 1
a. Compare and contrast:
Antigen/immunogen Antigens and immunogens both can illicit immune
responses, but an antigen may bind to an antibody without causing any type of
immune response unlike
Immunology discussion question 2
Serum from three species rat, horse, monkey was subjected to fractionation
procedures, and pure albumin was prepared from each. Three rabbits (1,2,3) were
immunized with rat, horse and monkey serum
3703 Discussion 7
1. Contrast T-independent and T-dependent antigens with respect to B cell
activation, memory, class of antibody produced, and molecular characteristics of
Parham pg. 250-255.
B cell binds to A
Inflammatory cytokines (KNOW THESE AND GO OVER THE FIGURE 3.9 IN THE CHAPTER FIGURES)
1.) Il1 (interluken which tells you that is was likely made by a leukocyte even though some are made
by endothelial cells)
2.) Il6 (interluken)
3.) TNF al
Natural Killer Cells (NK Cells or large granular lymphocytes)
Killer = kill virus infected cells as well as cancer cells
Natural = innate = ready to act
Lymphocytes means they relate to b and t cells.
They use pattern recognition receptors
31 August 30, 2016
Discussion Question 1
A. Antigen/ Immunogen
The antigen and immunogen both play a part in the immune response. An
antigen called an immunogen has the ability to induce an immune response
due to their
September 14, 2016
1. Immunosuppressant drugs were used following the bone marrow transplant
to suppress the immune system to avoid fighting the foreign cells from the
donor marrow that were introdu
Pathogen - any organism that causes infectious disease.
Two types of immunity: (.) Immune Response (IR)
1.) Innate/Non-specific (RS)
2.) Specific/adaptive (acquired)
Innate/non-specific - Born with and are ready to act immediately; within hours
Same molecule can be both secreted and membrane bound.
Naive cell has both IGM and IGG. These have different constant regions, but the same variable region.
Nave cell can become a memory cell with a different class bu
Effector Mechanisms of complement activation
1.) Opsonization: c3b or c4b bind to the pathogen and to complement receptor 1 (cr1) on the wbc
2.) Inflammation: c3a, c4a, and c5a are anaphylatoxins (they cause mast c
Complement, is a series of proteins in the blood and tissues in an inactive form. There are three
activation paths, and they have common effector mechanisms (ways of eliminating pathogens).
1.) Alternate path which is activated
Complement is a series of proteins in the blood that are all in an inactive form until they are activated in
a cascade form.
a.) The alternative path is activated when c3 binds to the surface of a bacteria or to damaged
Neutrophils are stored in the bone marrow. So, if you have no infection your blood would show numbers
on the lower end. However, when there is an infection, they are released into the blood and the measure
of neutrophils to rise to the hi
Acute phase response
Inflammatory cytokines stimulate the synthesis of acute phase proteins by the liver
1.) MBL Opsonin and activates complement through the lectin path
2.) CRP - Opsonin and activates complement th
3703, Disc 10
A woman was seen in a rheumatology clinic with stiff painful joints in her hands which
were worse first thing in the morning. Other symptoms included fatique, a low-grade
fever, weight loss, and a nonspecific rash on her face a