Lecture 3 exposure
What is exposure?
- Contact with the substance
- Swallowing, breathing, touching skin & eyes
- Ocular effects are different, so you need to separate skin from eyes, even
though the type of exposure is basically the same
55 gallon sealed
Death Cap Mushrooms
- Most dangerous mushrooms
- Initial symptoms are nausea, vomiting, diarrhea, and irregular heart rate.
- 0.1-0.3 mg/kg is fatal
- Fungal toxins (mycotoxins)
- Turkey X disease in England
+ Thousands of farm animal
Lecture 2 Notes part 1
- Any substance that is harmful to your body when ingested, inhaled,
injected, or absorbed through the skin (CDC)
- Includes natural and synthetic chemicals. Made by the dose.
- Can be intentional or unintentional. Drugs resu
Lecture 3 Notes part 2
- Typically breathe 10-20 m3 per day.
- People spend 90% of time indoors.
- Gases and vapors are absorbed throughout the respiratory tract.
- >10 microns are filterred to nasal cavity.
- <1 micron are deposited in pulmona
Lecture 3 Notes part 1
- Contact with a substance, typically by swallowing, breathing, or touching
the skin or eyes.
1. Source of Chemical
2. Chemical Transport
3. Point of Exposure
4. Exposure Route
4. Exposed Population
Lecture 5 Notes
What is happening in the body. How much toxin is absorbed, what organs
are effected, how do we excrete it?
What are the health effects?
Part of Toxicokinetics:
Absorption, Distribution, Metabolism, Elimin
Lecture 4 Notes
Founder of Toxicology
Paracelsus. Coined "The dose makes the poison".
Water and Toxicity
- Woman dies from water drinking contest due to dilution of sodium,
potassium, and calcium.
- Neurotoxin produced by gram positive bacteri
Lecture 6 Notes
Study of malformations. From greek for monster.
Abnormal or strange animal or plant.
History of Developmental Effects
2000BC: Tablet of Nineveh describes 62 malformations
1500: Malformations thought to be caused by the d
Lecture 7 Notes
Regulation of Ethanol
1981: U.S. Surgeon General first advised that women should not drink
alcoholic beverages during pregnancy.
1988: U.S. requires warning labels on all alcoholic beverages sold in the
1990: U.S. Dietary Guidelines s
What is a PBT (persistent bioaccumulative toxin)?
- A chemical that is persistent and bioaccumulative and toxic.
- Requires data on:
+ Persistence in soils, air, water, and sediment.
+ Bioaccumulative potential in tissue and among tr
This exam is open book and open notes. For the multiple choice questions, indicate your
answers clearly (by highlighted and or using bold face type). For the short answer,
matching and short essay sections, type your answers into the spaces provide