Do not exert a trans-dominant loss of function
The mutated P53 is not in a high enough concentration that you would expect
from the mutant p53 mutating permanently all the wt p53
Rare autosomal dominant inheritance
Why is the collection of a large samp
Acute promyelocytic leukemia fusion protein when exposed to ATRA (all-trans-retinoic
acid, an organic compound) it ceases to prevent differentiation. Combine ATRA with
arsenic trioxide. In the disease, RARalpha fuses to PML in a mix of chromosome 17 and
Human papilloma virus and cervical cancer
Cancer caused by a virus
Screaning is very important
Largely preventable with vaccination
HPV 16/18 is a very potent cancer virus because it makes two proteins, E7 that
binds to Rb, inactivating it and leading
The fruits of Long endeavors:
Her-2 is a receptor tyrosine kinase expressed in breast cancers.
Antibody made to inactivate it (a monoclonal antibody) called Herceptin.
They had to make a test where they exposed the antibody to cells expressing Her-2. They
Diagnosed from birth to 8 years
Two forms of this cancer: familial vs. sporadic
Familial form appears in children with an affected parent. Both eyes have tumors
(bilateral Rb) >500X increased risk for other cancers
occult tumor a tumor that is too small to be detected and does not cause the
manifestation of symptoms associated with cancer at the moment
micrometastases small deposits of tumor cells
Stage breast cancer by three things:
Chapter 6 Emperors (gleevac and herseptin)
The Bcr has three fusion sites. Chromosome 22 with a bit of 9. Philadelphia
chromosome, byproduct, if you have it you are producing BcrAbl protein
CML Chronic Myeloid Leukemia, massive, clonal expansio
Greider and Blackburn
telomeres enable cell replication, shorten, if too short the cell will go into
senescence. They act as a buffer and prevent chromosomes from sticking to one
another (aberrant ligation). They are the substrate for telomerase to add
Session 15: Telomeres, telomerase activity, immortality
Tumor cell growth are limited by tumor suppressive programs: apoptosis and senescence.
10^8 cells can see on xray. 10^9 cells, can feel physical, half centimeter to a centimeter.
Die when it overwhel
V-ras genes can act as initiators of two-stage mouse skin carcinogenesis
What we know so far: Cancer is a multistep process, therefore tumor is the end
product of multiple events. The exact number of events depend on the target cell,
proto-oncogenes can b
What role does tyrosine phosphorylation play in regulation pp60src?
The src gene is a Tyrosine Kinase
Kinases can phosphorylate themselves and be phosphorylated by other kinases.
527 not present in vsrc
416 present on both, but 527 part o
Metastatic non-Hodgkins Lymphoma
Reason why cancer kills (metastases). 80% of metastasized tumors are
carcinomas, number one cause of death in adult population.
Tropismsdifferent cancers like to see different organs. Breast cancer loves to go
to the bon
Carcinogens, DNA damage and genomic instability
Cancer risk is associated with environmental insults
1761 John Hill makes connection between snorting snuff with nasal cancer.
1775 Percivall Pott connects scrotal cancer to English Chimney sweeps.