INITIAL ENCOUNTER with germs, or pathogens, sets off
the innate" arm ofthe immune sgstem, which turns out
to be more sophisticated than angone guessed.
Bg Luke A. J. ONeill
The innate immune response constitutes the rst line
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Extraordinary Summer Programs for High Schooi Students
MCRB 410 Chapter 8 Notes
-the production of new lymphocytes (lymphopoiesis) takes place in
central lymphoid tissues: bone marrow for B cells and thymus for T cells
lymphoid precursors originate in bone marrow; B cell precursors
MCRB 410 Chapter 7 Notes
-intracellular signaling pathway = a series of proteins that interact
with one another to convey information received from the extracellular
environment across the plasma membrane in order to generate intracellular
-each receptor-chain variant cant be encoded in full in genome b/c
would require more genes for antigen receptors than there are genes in
entire genome; instead V regions encoded in gene segments that are
assembled by somatic DNA recombination
-classical pathway initiated when complement component C1
(comprised of recognition protein C1q and proteases C1r and C1s) recognizes
microbial surface directly or bind to antibodies bound to pathogen
-alternative pathway initiated by spontaneo
Chapter 2: Cells and Organs of the Immune System
1. (a) Myeloid progenitor. (b) Granulocyte-monocyte progenitor. (c) Hematopoietic
stem cell. (d) Lymphoid progenitor.
2. The primary lymphoid organs are the bone marrow and the thymus. There organs
Chapter 1: Overview of the Immune System
* Important Notes: If you see Ag, it is an abbreviation for Antigen, and if you see Ab, it is an
abbreviation for Antibody.
1. Jenners method of using cowpox infection to confer immunity to smallpox was
Chapter 3: The Innate Immune System
1. Cells of the innate immune system express a number of cytokines and chemokines
that recruit cells of adaptive immunity to the site of the infection. A key cellular
bridge between innate and adaptive immunity is the d
Micro 410 Study questions
1. Compare and contrast adaptive vs innate immunity.
2. Compare and contrast cellular vs humoral immunity.
3. Compare and contrast T cells and B cells.
4. Compare and contrast primary vs secondary response.
5. Which cells are in
Innate immune sensing and its roots:
the story of endotoxin
Bruce Beutler and Ernst Th. Rietschel
How does the host sense pathogens?
Our present concepts grew directly
from longstanding efforts to understand
infectious disease: how m
Mast cells and basophils
Stephen J Galli, MD
Mast cells and basophils are effector cells in IgE-associated
immune responses, such as those that contribute to asthma
and other allergic diseases and to host resistance to parasites.
Recent work shows that ma
Introduction to Immunoassays
Enzyme- Linked Immunosorbent Assay
How does one detect antigen-antibody binding?
Enzyme Linked Immunosorbent Assay or EIA
Several different types
MICRO 410 EXAM 2
About the Exam
Chapter 4-6 (and some techniques)
Dont need to know names
Bring your ID and a pencil
Same format and difficulty as exam 1
Advice for studying
Use Quizzes and homework
MICRO 410 EXAM 1
About the Exam
Location: 119 Osmond
Date/Time: 02/10 during class time
CHAPTER 1: BASIC
CONCEPTS OF THE IMMUNE
Def. The ability to resist infection
It can be transferred from on
PRINCIPLES OF IMMUNOLOGY
FALL SEMESTER 2016
MWF: 13:25 14:15 p.m.
022, Deike Building
Dr. Suresh Kuchipudi ([email protected] )
Associate Professor and Section head
1-Way MLR Test
Tests alloreactivity; 2 cell types are incubated together but
stimulator is treated with X-rays or mytomycin C to prevent
proliferation, 3H-thymidine uptake in DNA of responder is
recorded; greater different in MHC II classes = greater prol
STRUCTURAL STUDIES OF
Nobel Lecture, December 12, 1972
R. R. P O R T E R
Department of Biochemistry, University of Oxford, England
In 1946, when I was starting work as a research student under the supervision
of Dr. F. Sanger, the secon
Parentprogeny recognition as a function of MHC
K. Yamazaki*, G. K. Beauchamp*, M. Curran*, J. Bard, and E. A. Boyse
*Monell Chemical Senses Center, Philadelphia, PA 19104; and Department of Microbiology and Immunology, University of Ariz
NOVEL CRYSTAL BALL: One day Y-shaped molecules
called autoantibodies in a patients blood may tell
doctors whether a patient is brewing certain
diseases and may even indicate roughly how soon
the individual will begin to feel symptoms.
2002 Nature Publishing Group http:/genetics.nature.com
Paternally inherited HLA alleles are
associated with womens choice
of male odor
Suma Jacob1, Martha K. McClintock1*, Bethanne Zelano1 & Carole Ober2*
*These authors contributed equally to thi
REFLECTIONS ON SELF: IMMUNITY AND BEYOND
The Danger Model: A Renewed
Sense of Self
For over 50 years immunologists have based their thoughts, experiments,
and clinical treatments on the idea that the immune system functions by
Due: _January 29, 2016 (in class) _
*Homework is not a joint effort. You may consult your book or other sources
but please do your own work.
The following statements refe