The Mutator Hypothesis states that MMR (mismatch
repair) minus cells accumulate mutations in protooncogene and tumor suppressor genes.
Akylating agents destroy proliferating cancer cells that are
added onto DNA to prevent replication.
Source: ingestion of forages containing spores or organism
found in soil, decaying organic material (e.g. dead animals
in silage, dead fish etc)
Pathophysiology: blocks acetylcholine release at
Clinical signs: flaccid
('lipid-loving', dissolve easily in lipids), non-polar, and of
molecular weight are readily absorbed
through the cell membranes of the skin,
gastrointestinal (GI) tract, and lung.
Hard for the body to
eliminate and can accumulate
#1 poison control call resulting in fatality
general approach to the mgmt of the poisoned pt
1. contact poison control
2. first aid
3. supportive/symptomatic care
4. patient assessment
6. GI decontamination
What are the types of detergent surfactants?
Nonionic - neutral pH
Anionic - Sulfonated and phosphorylated hydrocarbons
Cationic - 4 ammonium compounds that contain halogen
What are some sources of the different types of
Nonioninc - hand, clot
the science of poisons
the science of toxicants, their physical and chemical
properties, sources, biological effects, mechanisms of
action, clinical signs, lesions, analyses, diagnosis,
differential diagnosis, and treatment/prevention o