Chapter 3 (dont panic, just a few final comments) Sanes, Reh and Harris Cell Division, Neuronal Birthdates, and Migration
SINGLE GENE MUTATIONS and NEURONAL MIGRATION Many Possible Causes: For example: High level X-rays Toxins Experimental gene knock-out
Critical or sensitive periods in brain development: its easier to make changes to the brains structure or
function by modulating the environment.
Sensitive period: no critical period, no perfect window. Things that we thought were critical periods. If
wont talk about in detail
have to get neurons where they need to go. Today is about migration. One of the
best ways to look at this is to use these same methods that mark cells during cell
division to see where they go.
Determination and Differentiation
some cells - final determination and differentiation occurs at proper spot.
in different places in nervous system, cells become differentiated as they go.
1. intrinsic factors (cell lineage)
2. extrinsic factors
Dont need to memorize four important Fgfs that play role in pathway of zig1 and zig3. If you wanted to
ask questions of what those 4 were doing. 2 are embryonic lethal (not after 4 th day in this case, 8th day in
other case). Problem isnt just with CNS, t
Neurons that are activated are all projected to same place. Organized method of
understanding visual world. How do we set these neurons up so that they function?
Specify through cell-cell interaction over time.
Take undifferentiated cells.
Segment Polarity Genes
engrailed (en) hedgehog (hh)
So we have two genes that are getting turned on, these are our major players. Name the segment
polarity genes: wingless and engrailed.
These two gene products c
Development of the Nervous System Chapter 3 Sanes, Reh and Harris Cell Division, Neuronal Birthdates, and Neuronal Migration
Important issues in chapter 3
1. Cell division in the vertebrate neural tube takes place near the ventricular surface. 1. Precurso
Development of the NS Sanes, Reh and Harris Chapter 1: Neural Induction
Have you handed in your Big Issues summary #1 via the Digital Dropbox? + Have you handed in your synopsis of the General Interest paper for Chapter 1? Good job
Important concepts from
Development of the Nervous System
Polarity and Segmentation Sanes, Reh and Harris, 2nd Edition
There are several important dimensions of polarity and specialization 1. Anterior-Posterior differentiation: brain to spinal cord 2. Dorsal-Ventral pa
PSYCHOLOGY/NEUROSCIENCE 269 BRAIN DEVELOPMENT
Credit: Gary Gaufo
DNA -(transcription)-> RNA -(translation)-> PROTEIN
SOMETIMES THE BRAIN DOESN'T DEVELOP NORMALLY: Developmental Disabilities
www.vanderbilt.edu Click on "LOGIN TO OAK" When you open NSC 269
SANES Chapter 5 Part 2:
Molecular mechanisms of axon guidance
adhesion-actin-myosin contraction-new actin-assembly for filopodial elongation-new adhesion make the growth cone move forward.
Remember that adhesion allowed the growth cone to be pulled forwar
Chapter 5, Part 3
Sanes, Reh and Harris Axon Growth and Guidance Pg. 139 Degeneration and Regeneration in the CNS 1. Neuronal Degeneration in the Adult Nervous System 2. Axonal Degeneration in the Adult Nervous System 3. Neuronal Regeneration in the Adult
Chapter 6 - part 1 Sanes, Reh and Harris Target Selection: Getting axons to their proper target
Challenges each axon faces in finding the right cell to synapse upon
Get off the beaten path
Remain in the right structure
Construct a map of t
Chapter 6 - part 2 Sanes, Reh and Harris Example maps in the brain and their construction
The 'little person' exists, but is very distorted by receptor density. The dermatomes on the left are mapped onto the cortical surface as shown on the right. Spinal
Chapter 7 Sanes, Reh, and Harris Naturally occurring neuronal death during normal development Part 1: pp. 173-192 November 29 is an interesting day: it is the day the first term papers are due
What is the function of cell death in nature?
Result of failur
Chapter 7 Sanes, Reh, and Harris Cell Survival and the Death Gene Part 2
Conferences on cell death are annual events This is the logo for the Fourth European Workshop on Cell Death in Istanbul in 2004, building on the work of this man:
H. Robert Horvitz n