Structure of the peptide bond
Carbonyl and oxygen amide hydrogen are in opposite alignment in
a trans configuration.
Peptide group has two permanent dipoles aligned in the same
Peptide bond has partial double bond character due to reso
I. (pleated) sheeti. general occurrence ii. extended conformation iii. characteristic
zig-zag pattern with side chains above and below the horizontal axis. iv.
stabilized by extensive hydrogen bonding between different segments of sheet
Prions Lecture: Misfolding Proteins
A 31-year-old male patient presented to the National Prion Clinic
in the United Kingdom in 2005 with a 6-month history of
progressive balance difficulties and impaired concentration. He
had incapacitating leg pain and i
Lecture: Abnormal Protein Folding
This abnormally folded protein then multiplies by inducing its
normal counterparts to change shape.
It is proposed that the normal cellular prion protein (PrPC) folds
into a predominantly -helical conformation, while the