Notes from Chapter One Immune System
Innate immune response:
The first is recognition that a pathogen is present
the second part of the response involves the recruitment of destructive effector
mechanisms that kill and eliminate the pathogen
Topic #1: Immune System: Introduction
Objective 2: Explain the immune mechanisms that establish the state of
inflammation in response to an infection. (innate response)
Immunology: study of physiological mech that humans and other
The most common mechanism of antibiotic activity is interference with bacterial cell wall synthesis.
Most of the cell wallactive antibiotics are classified as -lactam antibiotics (e.g., penicillins,
cephalosporins, cephamycins, carbapenems, monob
MICROBIOLOGY/IMMUNOLOGY March 11, 2016
1. Compare fungi and bacteria from a structural perspective.
2. Propose the primary reason why antifungal drug development may be more difficult than novel
antimicrobial drug discovery.
3. Given a community of hos
PHAR3417 Med Micro & Immunology Topic #6 & #7 Problem set
Topic #6 - BCR & Antibody Questions
What is affinity maturation?
What is isotype switching?
Why is isotype switching important?
Which immunoglobulin isotypes (out of IgM, IgG, IgA, IgE, an
Plasma cells secrete antibodies Fig. 4.1
Antibodies are very variable proteins. An individual antibody molecule is said to be specific; that is, it can
bind to only one antigen or a very small number of different antigens. The immune system has t
IMMUNOLOGY Chapter 2 (Figures)/ Chapter 3 (reading) Objective #6
Topic #2 Innate Immunity Part 1
Fig 2.3 Complement activation results in covalent
attachment of C3b to a pathogens surface.
The key event in complement activation in response to a
IMMUNOLOGY Topic 2 (Part 1) Chapter 2
2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens
Fig 2.1 Many barriers prevent pathogens
from crossing epithelia and colonizing
Surface epithelia provide mech
IMMUNOLOGY Topic 1
1-4: The Innate Immune Response causes Inflammation at sites of Infection
Innate Immune Response: a rapid response that is generic
Differs from adaptive immune response:
o Protects against a broad spectrum of pathoge