Chapter 9: p53 and Apoptosis: Master Guardian and Executioner
Organisms have a vital interest in eliminating defective or malfunctioning cells from
- the p53 protein serves as the local representative of the organisms interest.
P53 is prese
Apc facilitates egress of cells from colonic crypts
While the majority of colon cancers appear to be sporadic, a small group arises as a
consequence of inherited alleles that create substantial lifelong risk for this disease.
- the best understood is aden
Chapter 4- Cellular Oncogenes
Most types of human cancers did not spread from one individual to another as an
Of the hundred or more tumor types- only two were commonly occurring tumor
types in the western world- cervical carcinomas an
Cancer Bio Chapter 2 notes:
Individual cells- are endowed with great autonomy and versatility. Most types of
cells in the body carry a complete organismic genome. And many cells retain the
ability to grow and divide long after organismic development has b
Chapter 8: pRb and Control of the cell cycle clock
8.2 Cells make decisions about growth and quiescence during a specific period
in the G1 phase
All normal cells require external signals, such as those conveyed by mitogenic
growth factors, before they wil
Growth Factors, Receptors, and Cancer
How could a single protein species (such as src and ras) succeed in changing so
many different regulatory pathways at the same time?
Vital clues about oncoprotein functioning came from detailed studies of how
Chapter 14: Moving Out: Invasion and Metastasis
In the early phases of multi-step tumor progression, cancer cells multiply near the site
where their ancestors first began uncontrolled proliferation.
The result, usually apparent only after many years time,
Chapter 10: Eternal Life: Cell Immortalization and Tumorigenesis
During this extended period of development, populations of human cells pass
through a long succession of growth and division cycles as they evolve towards a
neoplastic growth state
- such ex
Cancer Biology Chapter 3 Notes
- They are infectious agents that do harm through their ability to multiply
inside infected host cells, to kill these cells, and to release the progeny virus
particles that proceed to infect other hosts nearby.
Cancer Bio Chapter 1
How does the genetic constitution of a cell and organism determine its appearance and
Molecular Biology: the study of biological and genetic processes to determine their
mechanisms of function.
Cancer is a disease of deregul
Chapter 15: Crowd control: Tumor immunology and Immunotherapy
Another line of defense against cancer cells- the immune system
- highly effective in detecting and eliminating foreign infectious agents
o viruses, bacteria, and fungi from our
Chapter 11: Multi-step Tumorigenesis
Normal cells evolve into cells with increasingly neoplastic phenotypes through a
process called tumor progression.
Tumor progression is driven by a sequence of randomly occurring mutations and
epigenetic alterations of
Chapter 7: Tumor suppressor genes
The discovery of proto-oncogenes and oncogenes provided a simple and powerful
explanation of how the proliferation of cells is driven.
- the proteins encoded by proto-oncogenes participate in various ways i
Chapter 6: Cytoplasmic signaling circuitry programs many of the traits of cancer
Cancer is a disease of uncontrolled proliferation.
Normal cells and cancerous cells utilize control circuitry that is almost identical.
- Cancer cells discover ways of making