Lecture 14/15 Molecular Biology 10/21/08 Exam next Tuesday Covers up to Transcription Nuclear polymerases dont bind to the DNA very well so have factors which help them bind Basal Factors for RNAPII (Class II promoters) -TFIID (TBP) (initiation) -TFIIB an
10/23/08 Bio 344 Transcription Activators 1. Modular a. DNA binding Domain b. Activation domain 2. Bind to the upstream on regulatory sequences -enhancers-> Orientation and position-independent -silencers -insulators *35S-uses combinatorial regulation, ex
344 11/18/08 Exam III Thursday -Covers lecture 16- lecture 22 -bring pencils and pin -Huks lecture 16 Pol IV not DNA dependent Pol 1,2,3 are all DNA dependent HCPro was discovered by Vicki Vance MicroRNAs sometimes called non-coding RNAs specifically micr
Gene Expression: The Flow of Information
from DNA to RNA to Protein
2 major questions
How is genetic information encoded?
How does information transfer from DNA to
Genetic Code characteristics
Code is in
DNA Replication & Recombination
How does DNA replicate?
How is replication done accurately?
How does recombination occur?
Challenge of Replication
Example: Human DNA
3,000,000,000 base pairs on 23 chr