EX: 7 AA "word"
You can find this sequence in these 2 completely different enzymes (7 AA's are in red [in 1st pic, it's in alpha
helix; in 2nd pic, it's in beta sheet)
Chameleon sequences - sequence which could have 2 different "meanings;"
Changing humidity changes DNA structure (by content of water) from structure "A" to "B [has a higher
content of water than A]"
Originally thought DNA was triple helix with phosphates on the inside and bases on the outside
Folding problem - given a series of AA, you don't know how they will fold
3 parts to the folding problem
Levinthal's Paradox - protein must fold in a reasonable amount of time
Bernal said we're far from solving the folding problem
Sequence space - a collection of unique sequences; a "map" of sequences
How did nature pick one unique sequence out of this map?
Considering 2 types of amino acids - polar (P) [the black balls are hydrophobic] or