Hemoglobin exists in two conformations, R and T, which differ in quaternary structure. The difference involves a
shift of the subunit positions relative to each other. Deoxyhemoglobin is primarily in the T state, but oxygen
binds preferentially to the R s
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Hydropathy plots show the hydrophoblc nature of polypeptide reglons. They can be used to locate a hell
transmembrane segments in a polypeptide.
Identify which segment(sr) of the polypeptide characterized in the hydropathy plot below could bel
An oligomeric protein has a molecular weight of 435000. A 470 mg sample was treated with an excess of
1-uoro-2,4-dinitrobenzene (Sanger's reagent) until the reaction was complete. Next the peptide bonds
were hydrolyzed by heating with concentrated HCI. Th
Calculate the number of millimoles of protein in the sample from the mass and molecular weight:
470 mg protein
=0.0011 mmol protein
The molecular weight of the clinitrophenyl-phenylalanine from its formula, C15H13N306, is 331.28.
llagen, a strong fibrous protein found in connective tissue, bone, and the extracellular matrix, has a
ucture in which three helices wind around each other to form a triple helix.
Answer parts a. b, c, and d below.
a) The following sequence represents
Determine whether each of the following carbohydrates is a monosaccharide, disaccharide, or polysaccharide.
Monosaccharides Disaccharides Polysaccharides
OH O OH OH glycogen
0. 0H (MKP
HOCHg 0 0H
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If a solid line represents a covalent bond and a dotted line represents intermolecular attraction, which of
these choices shows a hydrogen bond? Check all that apply.
7 Explanation @ Previous 9 View Solution Check
Kimchi is traditional Korean food made by fermenting cabbage or other vegetables in a mixture of spices and
salt. Kimchi originally developed as a method of preserving vegetables before the advent of modern
refrigeration. Why does the use of a salt soluti
Both DNA and RNA are polynucleotides, with the nucleotides connected in a phosphodiester linkage between
the 3 position of one sugar and the 5' position of the next sugar. Both contain the purines adenine and guanine
and the pyrimidine cytosine attached t
Classify the molecules as hydrophilic, hydrophobic. or amphipathic (amphiphilic).
Hydrophilic Hydrophobic Amphipathic
@ Previous 9 View Solution @ Check Answer 6 Next Exit
drophilic ("water-loving") molecules are polar and can form e
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Human Herpes types
Tar at cell . .
Herpes simplex-2 (HSV- Alphaherpesvirinae Mucoepithelia Close contact usually
Varicella Zoster virus . . . . Contact or respiratory
Groups to the right in the Fischer projection will be "down" on the ring; groups to the left in the Fischer wil be "up"
on the ring.
The position of the OH group on the anomeric carbon atom, carbon 1, distinguishes the a and [3 anomers. In the
a anomer th
A protein biochemist attempted to determine the amino acid sequence of a decapepde. Use the results 393%
from the trypsin, chymotrypsin, and cyanogen bromide treatments to suggest the amino acid sequence of
Trypsin digestion gave two fra
the ability of a liquid to ow up a narrow tube
unassisted against gravity
the attraction between molecules of the same
the curvature of the surface of a liquid at the
0) WhiCh 0f the fOIIOWilIQ bonds ionic bonds between side chains of adjacent helices
stabilize the collagen trIple helix?
interstrand hydrogen bonds between backbone NH and 0:0
intrastrand hydrogen bonds between backbone NH and C=O
st collagen is composed of three helical pol peptides that pack together to form a triple helix, which further
semble Into collagen fibrils. The collagen he ix is distinct from the a-helix in that it is left-handed and has three
amino acids per turn. In o
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Collagen, a strong fibrous protein found In connective tissue, bone, and the extracellular matrix, has a
structure in which three helices wind around each other to form a triple helix.
Answer parts a, b, c, and d below.
a) The followi
A sample of an unknown peptide undergoes a single round of Edman degradation, which liberates ATZ-Gly.
Another sample of the peptide is treated with trypsin, and a third sample is treated with chymotrypsin. The
table below shows the fragments. Complete pa
Met Va | Lys Tyr x x x x x x
The order of the CT2 fragment is Thr-Trp, since chymotrypsin cleaves after Tyr and Trp. The order of Pro and
Phe is already known, and Ala is the N-tem'linal amino acid for the tetrapeptide, so the decapeptide sequence
0 14 CHZOH
Oligosaccharides are composed of three to 10 monosaccharide units. Polysaccharides are long chains of more
than 10 linked monosaccharides. Starch and glycogen are composed of hundreds of glucose residues. The
Hemoglobin subunits lack the sigmoid binding of quaternary hemoglobin and show a hyperbolic binding curve,
similar to that seen for myoglobin.
These effects can be summarized in a brief equilibrium expression. where protons, 002, and
OH OH OH 0 0
OH O CHZOH HO
0 0H 0H
,9 - D - galacto pyranose 5 - L -gluco pyranose 3 - D - fructo furanose
(9 Previous 9 View Solution Check Answer 6 Next Exii
e a or [3 terms refer to the conguration at the anomeric carbon, whi
Aldonic and uronic acids have carboxyl groups at a terminal carbon of the carbohydrate chain. Aldonic acids are
formed from the oxidation of the terminal aldehyde, whereas uronic acids are formed from the oxidation of the
terminal hydroxyl. Aldonic acids
Glycosaminoglycans (GAGs) are heteropolysaccharides composed of repeating disaccharide units. One of the
monosaccharides is either Nacetylglucosarnine or N-aoetylgalactosamine. and the other is generally a uronic
Structure A is the glycosami
A small generic section of the primary structure of an a helix is given below.
amino acid1amino acidz amino acid3 amino acid. amino acids amino acids amino acidy
(a) Which amino acid residue's backbone forms a hydrogen bond with the backbone of