Aplastic Anemia BM cant produce RBC
Cellular depletion and fat tissue replacement, <25% cellularity and
low numbers of at least two blood cell types. Can be due to drugs,
chemical, irradiation, infections and immune disorders. It appears
2. The most common NH lymphoma world-wide is
a. Burkitt lymphoma
b. follicular B cell lymphoma
c. marginal zone lymphoma
*d. diffuse B cell lymphoma
e. peripheral T cell lymphoma, unspecified
4. Which of the following statements about multiple my
1. Leukemia is best defined as a
a. malignant disease of blood cell types focused in the peripheral tissues such as liver, spleen, and lymph
b. malignant disease that is always rapidly progressive and invariably fatal.
*c. malignant disease of hema
1. CML is
a. a classic leukemia with a mutation in the JAK2 gene that occurs in a myeloid progenitor cell.
b. an acute leukemia despite its name.
c. the same thing as polycythemia vera.
d. associated with the Philadelphia chromosome, which is an abnormal
Hematology Exam 3 Study Guide
Normal morphology. Reference Value 150 400 x 10^3 microliter
Thrombocytosis: an increased number of platelets. So they are clumped
together, most likely due to in vitro placement. Some can be s
1. Identify the white blood cell.
a. Reactive lymphocyte
d. Small lymphocyte
e. Large lymphocyte
2. Ignore the center abnormal white blood cell! Looking at the rest of the picture, what white
blood cell types can be see
*a. results from a somatic defect in the PIG-A gene in a single hematopoietic pluripotent stem
cell that leads to red cells that cant protect themselves from activated complement proteins.
b. is a congenital disease resulting from a mutati
1. G6PD deficiency is a mutation in an enzyme in the
a. Embden-Meyerhof pathway which leads to decreased ATP production in the red blood cell.
*b. hexose monophosphate shunt (or phosphogluconate pathway) which ultimately leads to decreased
1. Which of the following statements about malaria is/are true?
*a. Malaria is associated with a normocytic, normochromic anemia.
*b. Hemolysis of red cells occurs intravascularly in malaria, resulting in a hemolytic anemia.
*c. The diagnosis of
1. A patient with a fever is seen is a small clinic that lacks an automated cell counter. The
clinical hematologist working in the clinic dilutes the blood in WBC diluting fluid to a final
dilution of 1/100. The total number of WBCs counted in each of the
1. A patient suffering from chronic fatigue is seen in a clinic. A CBC is done and the MCV value
for the red cells is 74 and the MCHC is 29%. Which of the following would be the most important
test(s) to do next?
a. total serum iron and total iron binding
1. What are some of the abnormal red cell types/inclusions that can be observed in the Wright stain of a
peripheral blood smear from a patient with some form of anemia?
a. Howell-Jolly bodies
d. Heinz bodies
Type: MA (multiple answers are correct)
1. The unique characteristics of the pleuripotent hematopoietic stem cell include that they
a. are self-renewing (regenerate themselves).
b. can divide and produce mature progeny.
c. can produce all the lineages of
1. The roles of the blood vessel in controlling clotting/bleeding include
*a. contraction of smooth muscle in the media of an injured vessel, constricting blood flow to
*b. exposure of the basement membrane (aka the subendothelium