The article Defining Single Molecular Forces Required to Activate Integrin and Notch
Signaling by Xuefeng Wang1 and Taekjip Ha (Science. 2013 May 24; 340(6135): 991994.
doi: 10.1126/science.1231041) reports information about multicellular processes relate
Exam 1 Review
September 24, 2014
12 short answer questions
Best 10 graded
Fundamental Process of Cell Biology
Many many more copies of proteins
Figure 1-5 Molecular Biology of the Cell, Fifth Edition ( Garland Science 2008)
Exam 3 Review
General idea about mech forces
What kind of Mech forces are in the body? Mech
forces the cell experience?
forces from neighboring cells and extracellular
matrix that push and pull on them, and thereby
govern their growth and function
Food for Thought:
Stem cells in plants are localized in meristems
Shoot apical meristem
Root apical meristem
Lateral or axial meristems
Cell fate in root is determined by position
The pathway from DNA to protein. ?
The flow of genetic information from DNA to RNA (transcription) and
from RNA to protein (translation).
How to control what a cell is?
The most important thing in the cell is the protein because they define what the cell
What are they trying to measure inside the cell
If we want to understand whats going on inside the cell you really interested
in the protein that are on the cell ( every cell have the same DNA so looking in
the DNA not going to help you determine) so you
What is mechanobiology?
How cell response to forces
Forces the cell experience? ( Types of forces)
Fluid Shear Stress (fluid across cell its a frictional )
Stretch (lung stretch)
Pressure (blood pressure)
ECM contraction, neighbo
1. Why do you expect to encounter a STOP codon about every 20 codons, or so, on average in a
random sequence of DNA?
Hypothetically, each of the 64 different codons will appear with equal frequency.
Because 3 of 64 are stop codons, they're expected to occ