Thermodynamics and Kinetics with Applications to Biomolecules
CEM 882

Spring 2014
CEM 882 Homework 3: Due Wednesday February 26, 2014 in class
1.
Consider a 100residue protein where each residue can adopt either helical (A) or strand
(B) conformation. Consider that the folded state of the protein has conformation A at each
residue. Co
Thermodynamics and Kinetics with Applications to Biomolecules
CEM 882

Spring 2014
CEM 882 Homework 2: Due Wednesday, February 12, 2014 in class
1.
Consider the following model for the backbone of a 100residue protein. For each residue,
there are three possible sets of dihedral angles. In the unfolded state, there is equal
probability
Thermodynamics and Kinetics with Applications to Biomolecules
CEM 882

Spring 2014
dU = TdS pdV + dN
(1.68)
This equation is consistent with:
U = TS pV + N
(1.69)
DB, pp. 108109 considers the possibility of having a mixture of protein molecules in the
solution. In this case, there will be a chemical potential j and term jdNj or jNj ass
Thermodynamics and Kinetics with Applications to Biomolecules
CEM 882

Spring 2014
CEM 882 Exam #1 Review Sheet
The exam will be given on Thursday, March 13, 2014 at 3:00 p.m. in room 581W Chemistry.
You should bring a calculator to the exam. You may also bring one sheet of 8.5 11 paper containing
whatever handwritten and nonxeroxed i
Thermodynamics and Kinetics with Applications to Biomolecules
CEM 882

Spring 2014
CEM 882 Homework 1: Due Friday, January 24, 2014 in class
1.
2.
Consider the structural model of amyloid in Overhead 9.
a. (30 points) Use the model to quantitatively calculate in to 5 each of the crosssectional dimensions of the amyloid fibril. You shoul
Thermodynamics and Kinetics with Applications to Biomolecules
CEM 882

Spring 2014
1. Thermodynamics/Statistical Mechanics
1.A. Probability and entropy
Thermodynamics/statistical mechanics deal with the average properties of a large group of
molecules. Many biochemical experiments are done on large groups (often called ensembles) of
mol