Pathology Lecture 4: 3240 Cell Injury, Adaption and Death II
Reversible/ irreversible cell injury
Mechanisms of cell injury
If cell gets injured-> apoptosis or reversible cell injury or subcellular alterations.
Key cellular tar
Pathology of Infection
Introduction and Basic Principles.
Causes of cell injury: metabolic, physical, chemical, immunological etc.
Infectious pathology is the most common form of organic and cellular disease.
It is often mild and the pathology goes virtua
Pathology 3240 Lecture 2: Causes of Disease 2
Classifying cause of Disease: Genetic or environment?
General classification of what causes diseases. Diseases result from a variable interaction
between the host (genetic) and environmental host. Most are mul
Part III: AutoImmunity and ImmunoDeficiency
Lupus etc that have an autoimmune component
Occurs due to a breakdown of the normal processes which maintain a state of
immunological tolerance to self-antigens
Failure of self toleran
Disorders of the immune system may be broadly divided into:
In general, hypofunction or immunodeficiency results in two main forms of disease, as you
would expect if you recall, the two basic functions of
Hemorrhage and Shock-Pathology
Hemorrhage: A discharge or escape of blood from the blood vessels into.
Exterior of the body
A body cavity
Causes of Hemorrhage
Trauma to large blood vessels: Surgery, Fracture
Weakened large blood vessel
Disturbances of blood flow and body fluids Pathology
Vascular Hemodynamics Abnormalites
Blood flow-normal fluid homeostasis
Maintenance of blood as a liquid
Survival of cells and tissue is depen
Pathology Metabolic and Nutritional Disorders Part I
Many are genetically inherited and represent disorders in the metabolism, use of storage
of amino acids, carbohydrates or fats.
Others are acquired and may be consequence of sequelae of other conditions
Pathology- Disturbances of blood flow and body fluids
Blood flow: Hyperemia.
Maintenance of blood as liquid- Thrombosis
Hyperemia and Congestion: Both indicate a local increased volume of blood in particular
tissue, but they have differ
May be acquired transcervically (ascending) or transplacentally (hematologically)
Tumours of infant childhood as well
Spread of infection from cervicovaginal canal
Congenital and Genetic Disease
What is the difference?
Congenital Diseases: present at birth, can be due or not due by genetic defects
Genetic disease: Determined by genes, expressed later on in life
What is a congenital abno
Path Lecture 6: Inflammation Lecture 1
Inflammare: latin meaning to excited
Reaction of living tissue to injury
Dynamic process that starts with the injury and culminates with healing or repair.
Is primarily a defense mechanism but it may be potentially h
Pathology 3240 Lecture 1
Pathology: the study of disease. Pathos= disease or suffering logos: study.
It is the link between the clinical and basic sciences.
Knowledge about human disease come from observations made on patients-> clinical
pathology: the st
DR. BERTHA GARCIA
PATHOLOGY, UWO & LHSC - UNIVERSITY CAMPUS
GENERAL OBJECTIVES OF LECTURES:
Acquaint the student with a most important mechanism of defence without which the mammalian
organism cannot survive.
Explain and illustrate with exa
IMMUNITY AND IMMUNE DISORDERS
DR. CHRISTOPHER HOWLETT
DEPARTMENT OF PATHOLOGY
Part I: Biology of the Immune System
After completing this review you will be able to:
Define immunity and immunology.
List the general differences between the innat
Pathology- october 9th 2013.
The patient underwent a right hemiglossectomy with neck node dissection
Examination of the specimen showed an infiltrating squamous cell carcinoma
Although the resection margins were free, presence of metastatic tumour in 2 ou
Lecture 9: Regeneration and Repair
How are the tissues restored?
By: 1) removal of exudate 2) removal of cellular and tissue debris 3) replacement of cells
and tissues lost
Replacement of cells and Tissues
a) Regeneration: if the cells (or tissues) replac
Pathology: 3240 Lecture 3
Cells must react and adapt to changing internal and external environments in order to
When the environment changes exceed the capacity of the cell to maintain
homeostasis we see cell injury.
All injury starts at the cell
Pathology Lecture 5: Cellular Injury, Adaptation and Death II
Irreversible cell injury. Apoptosis vs Necrosis
2 features of Irreversible cell injury:
Inability to reverse mitochondrial dysfunction
Severe disruption of membrane function
The point that the
Pathology lecture 7
Macrophages (monocytes) very important, #1 source for most of inflammation. have
different names. Including: Dendritic cells in lymphoid tissue, Kupper cells. Alveolar
macrophages, histiocytes, inflammatory macrophages, microglia, oste
REGENERATION & REPAIR
DR. B. GARCIA
PATHOLOGY, UWO & LHSC - UNIVERSITY CAMPUS
GENERAL AND TERMINAL OBJECTIVES
To illustrate the mechanisms involved in the healing process.
and, at the end of this chapter, the student should be able to
define and contras