CSB331 Cell Dynamics During Development Course Outline
Jan 7 Lecture 1 Overview of course and embryonic development Cell-cell attachment: Jan 9 Lecture 2 Adherens junctions Jan 14 Lecture 3 Desmosomal junctions Jan 16 Lecture 4 Tight junctions, formation
Pemphigus foliaceus sera contain only antidesmoglein (Dsg) 1 antibodies and cause
blisters by interfering with the function of Dsg1, where there is no Dsg3 to compensate,
namely, in the superficial epidermis of skin.
In early pemphigus vulgaris, when pati
-have to form adheren jxn first before forming others (desmosomes and tight jxns)
Intermediate filaments: no polarity, no motors
-tensile structure of the skin
Central stratum: not there at early stage, stabilizes desmosomes, hyperadhesive
claudin 1 is important in regulating water transport.
Transporters for sugar transport.
Variability in the epithelium. (Fence and paracellular)
EL1- Basic and acidic residues varies depending on the amino residues
crosslinking domains have poly alanine structures with lysines separated by 2 or 3 lysine
crosslink that form with lysine residues are in pairs - 2 from one chain and 2 from the other
it is only alpha helical after it is crosslinked, not before