Slide 27: there is a strong interaction between PDK-1 and 3-PIs than for the other, it just needs the
modification to occur.
Sos, there are fruit fly genetics for years (until back in china collected cool mutation of things).
People collect dif
Mutation in dogs cause 6 toes, you sequence 100 other dogs to look at the dogs that
have the mutation but dont have 6 toes- hence you find a repressor of the mutation.
Ex. Look for people with HIV-1 and HIV-2 but they dont have aids sequence their
The major effector of PIP3 are PTKinase (have PH domains).
PDK-1 is a serine thr kinase. PDK-2 and also know as AKT is a ser-thr kinase. The signal spreads
out and things change once you activate PI3K.
One of the most important change h
Lecture 1 Notes
Signal transduction- the pathway in which the components in the pathways are activated through
previous signalling. This is something that normally happens.
How they are interpret for a cancer to grow?
How can you get cancer? Many of the p