L4-6 Principle Inhibitory Neurotransmitters GABA and Glycine
When we consider inhibition in the nervous system, the key transmitters are
o GABA, /Gamma amino buteric acid (butane with a carboxylic acid group
and an amino group on the fourth [/gamma = 4th]
L14-16- LIGAND BINDING
Even though the ligand binding occurs extracellular, the conformational
change propagates so that there is a conformational change in the
intracellular component of the receptors.
o The G proteins, as previously mentioned, are prese
L18-19 G PROTEIN COUPLING
o Coupling by G proteins directly to an ion channel.
This is the fastest (~100 ms), but not as fast as ionotropic reaction.
o Coupling by G protein to a second messenger system, where the 2nd
messenger (for example, cAMP or cGMP
L17- G PROTEIN COMPOSITION
o There are 20 different /alpha subunits
o There are 5 different /beta subunits
o There are 12 different /gamma subunits.
o Therefore, there are 1200 possible G proteins, most of which actually
Why are there so many more
o The /alpha dissociates from the /beta - /gamma and, though incorrect in
the diagram, remain tethered to the membrane.
o The /alpha subunit goes off and finds an effector protein to which it
attaches to, and remains attached as long as it is in th
L22-23 (Q and A session for anat component)
Which of the following organs or structures would be found in the left
iliac region? Intestines
Represented by the flow of charged
particles along a conductor, or the
flow of ions across a membrane.
L10-13 Introduction to Metabotropic Receptors
The synapses in the central nervous system undertake two types of synaptic
o Ionotropic neurotransmission, which leads to an EPSP (Na+inflow) or IPSP
Nicotinic receptors, such as th
L1-3 Ionotropic Receptors
The ionotropic receptors that control inhibition are involved in the fast
inhibitory transmissions that occur within the central nervous system.
We specify that inhibition occurs within the central nervous system, whi
L7-9 MEMBRANE POTENTIAL + NT EFFECTS
The Nernst Equation
If we consider the permeability of, for example, potassium, to be 1, that is, the
potassium ions are able to freely move through the membrane, in either
direction, and we consider the permeability o