Lecture #7: Hemolytic Anemias
Intracorpuscular Defect, Hemoglobinopathies (defects in hemoglobin)
Abnormal hemoglobin synthesis
The Hb thats made isnt functioning properly. Its the Hb itself thats the problem.
1. >625 variants described
Fetal Hb has no
RBC Structure and Function
3 areas of metabolism important to survival
1. RBC membrane
2. Hemoglobin structure and function
3. RBC metabolic pathways
RBC membrane very complex and elastic - 3 layers
Lecture 3: RBC Aging / Hemoglobin structure and function
RBC Aging Cycle
Each day 1 % RBCs (old) are removed from circulation and are replaced by young RBCs.
Reticuloendothelial macrophages (RES) perform the task.
B. Ageing is caused by the loss of g
Macrocytc Anemia (big RBC)
Megaloblastic Anemia anemia relates with defectve DNA synthesis. Should be
dyspoiesis (abnormal synthesis of all the blood cells because the defect is in DNA
synthesis) drugs, defect in p
Lecture #9: Anemia
Impaired DNA synthesis
Not a problem with young people unless theres a genetic defect.
Happens in the older population DNA accumulated mutations.
Mitosis is slowed
Manifested by the presence of megaloblasts i
Lecture 4: Anemia / Iron deficiency
The inability of blood to supply adequate amount of oxygen to tissues
Accurate diagnosis allows the appropriate therapy.
Three basic situations with anemia
1. Decreased hemoglobin
moderate 7g to 10 g
Hereditary Enzyme Defect (intracorpuscular) intra = defects that occur within
Plantation workers in Panama were given the anti-malarial, primaquine.
Many developed a hemolytic anemia of rapid onset.
People didnt know what the defect was unt
Lecture 5: Hemolytic anemias
Shortened RBC life span
Normal bone marrow can support decreased RBC life span down to 15 to 20 days. Decreased
marrow function will lengthen the needed RBC longevity.
1. Intracorpuscular defec
Lecture #8: Hemolytic Anemia, Thalassemia
Defective production of the globin portion of the hemoglobin molecule. (only shortages of alpha and
beta Hb is a concern)
1. Abnormality in the rate of synthesis of types of globin chai