Stress effects on the hippocampus
and prefrontal cortex
Overview for today
Overview of the stress response
Shutting Off Stress Response
Neural structural outcome of chronic stress
Genomic versus Non-genomic effects
Lectures 8 & 9: Brain Injury
1. Describe a brain injury.
-a blow to the head or body causing the brain to move rapidly within the skull causing brain
function to change either temporarily or prolonged
-can be serious and life threatening if not properly m
Lectures 10 & 11: Stroke
1. What is a stroke?
-caused by disruption of blood flow to part of the brain
-deprives neurons and other cells of glucose and oxygen leading to cell death
-results in impaired or lost function
2. What percentage of cardiac output
Lecture 22: Parkinsons Disease
1. Describe the pattern of Lewy body accumulation according to Braak staging.
-abnormal accumulation of the protein alpha-synuclein bound to ubiquitin in the damaged cells
-protein accumulation forms inclusions called Lewy b
Neuropathology of Motor Neurodegenerative Diseases: Huntingtons Disease
-strong genetic inheritance pattern in Huntingtons disease
-part of Huntington gene (Htt) is a repeated section called a trinucleotide repeat
varies in length between
About Prion Disease
-prion disease or transmissible spongiform encephalopathies (TSEs) are a family or rare
progressive neurodegenerative disorders that affect both humans and animals
-prion disease distinguished by
long incubation periods
Lecture 5: Common Neurodegenerative Pathways
1. What aspects of neurodegeneration are experienced during aging?
-increased oxidative stress
-perturbed energy homeostasis
-accumulation of damaged proteins
-lesions in the nucleic acids of cells
2. List the
Lecture 23: Huntingtons Disease
1. How does the normal Huntingtin protein contribute to neuroprotection via transcriptional
regulation and what is the effect of the mutant Huntington protein on this function?
-proteasome activity protec
Lecture 24: Amyotrophic Lateral Sclerosis
1. What are the 3 major families of superoxide dismutase?
-the Cu/Zn type (which binds both copper and zinc)
-Fe and Mn types (which bind either iron or manganese)
-Ni type, which binds nickel
2. What are the 3 fo
Lectures 12 & 13: Alcohol & Drug Use as Risk Factors for Neurodegeneration
1. Describe the paradox of addiction.
-how can a person develop and maintain a pattern of behaviour that is so obviously destructive
to their life?
-no answer but many theories
Lectures 16 & 17: Multiple Sclerosis
1. What is the age group most often diagnosed with MS?
-young adults aged 15-40
2. What is Multiple Sclerosis?
-disease characterized by damage to myelin in the motor and sensory nerved
-sometimes the actual axons are
Lectures 18 & 19: Alzheimers Disease
1. Describe Alzheimers disease.
-a progressive neurodegenerative disorder
-plaques and tangles form in a pattern beginning in areas important to learning and memory
then other areas
-cause neurodegeneration and a loss
Lecture 4: Vulnerable Brain Regions
1. Individuals with damage to their hippocampus show what kind of memory deficits?
-prevents the acquisition of new episodic memories
2. Define long term potentiation and describe the details of the process.
Lecture 2: Perspectives on Adult Development & Aging
1. What is aging?
-a complex biological process in which changes at molecular, cellular, and organ levels results in
a progressive, inevitable, and inescapable decrease in the ability of the body to res
Alcohol & Drug Use as Risk Factors for Neurodegeneration
Glutamate/NMDA Receptors: Acute Ethanol Effects
-NMDA ionophore receptor channel complex has 4 sites of action
1. a neurotransmitter recognition site where the agonists (glutamate and NMDA) bind
Alcohol & Drug Use as Risk Factors for Neurodegeneration
Drugs of Abuse & Addiction
-the controlled substances act of 1970 established a system to classify the abuse potential of
drugs known as the Schedule of Controlled Substances
-the schedule excludes
Questions from Aging
List and define the four key features of the lifespan
List the four forces of development and provide an
example of each.
List and define (elaborate on) the three main
components of successful aging.
Running head: RISK AND TRUST IN INTERNATIONAL CONSTRUCTION
The Role of Risk and Trust in International Construction Contracting
Little facts are known about trust as an instrumental in establishi
The use of qualitative case studies in top business and management journals: A quantitative
analysis of recent patterns.
Case studies are used in social sciences as qualitative research
Argument on Success
Name of Professor:
Over the years, most of the individuals have had the tendency of confusing winning to
success. The two terms look almost similar from the point of ordinary perception. How
Impact of Emotional Intelligence to Effectiveness of leaders in Healthcare
Over the years, Emotional intelligence (EI) has been one of the conceptual framework
5ICM ILD107001 - Student
CIPD Candidate Assessment Activity
Title of unit/s
Implementing coaching and mentoring
1. Executive briefing
2. Set of recommendations and support proposal
Lectures 14 & 15: Prions
1. What are protein chaperones?
-most proteins fold into 3D shapes
-many can fold unassisted through the chemical properties of their amino acids but others
require the aid of chaperones to fold into their native states
Lecture 21: Risk Factors for Motor Neurodegenerative Diseases
1. How is Parkinsons disease effected by dopamine?
-dopamine producing cells in the substantia nigra are lost in Parkinsons
-results in severe dopamine depletion in the striatum which is respon
Alzheimers Disease I
-in 1901, Alzheimer observed a patient at the Frankfurt Asylum named Mrs. Deter
-51 year old patient has strange behavioural symptoms, including a loss of short-term memory
-in 1906, Mrs. Deter died and Alzheime
-the sequence of amino acid residues in a protein is defined by the sequence of a gene
DNA to mRNA
-residues in a protein are often chemically modified by posttranslational modification
alters the physical and chemical properties
Lecture 20: Clinical Symptoms of Motor Neurodegenerative Disease
1. Describe Parkinsons disease.
-chronic, progressive, neurodegenerative disorder
-genetic and environmental risk factors, but no known cause
-risk increases with age
-usually in 60 and over
Multiple Sclerosis: Inflammation
Quick Facts on Multiple Sclerosis
-Canadians have one of the highest rates of MS in the world
-MS is the most common neurological disease affecting young adults in Canada
-women are more than three times as likely to devel