Chromosomal theory of inheritance
A collection of studies revealed that genes are
on chromosomes. In fact, multiple genes are
present on each chromosome.
What is a chromosome? How many do we have?
pair of matching
Lecture 3. Cats are not peas
There are multiple alleles for genes
Multiple genes determine phenotypic traits.
(Dihybrid ratio (9:3:3:1) and modified dihybrid ratios)
Statistical tests of genetic models
Can you always see the phenotype?
Module 1: Gene to protein
Genotype to phenotype in sickle cell disease
Mendels first principle: the segregation of alleles
Basics of probability and inheritance
Molecular genetics in sickle cell disease
Terminologies: dominant and recessive ar
Module 1: Population genetics
The gene pool
Mechanisms that alter allele frequencies
Applying theory to sickle cell disease
Society and (mis)understanding genetics
As we talk about population geneti
What is the difference between a qualitative
characteristic and a quantitative characteristic?
The genetics of
The influence of the
Protein Transport and Targe/ng
Fig. 3 A 3D model of synaptic architecture.(A) A section through the synaptic bouton,
indicating 60 proteins.
B G Wilhelm et al. 2014
Published by AAAS
! Ofce hours: !
! ! Wednesday 12:30-14:30!
! By appointment any day 9:00-21:00!
Instructor contact: emails must include ISCI 2A18 in subject !
! line or they may not be read (and wont get answered
Wrapping up nerve transmission
What Hodgkin & Huxley did
Getting to the synapse
The action potential, from the GHK perspective
RT pK [K ]o + pNa [Na ]o
pK [K ]i + pNa [Na ]i
The Action Potenti
Wrapping up with channels and transporters!
The membrane potential, Vm!
The action potential
Channels are transmembrane (TM) proteins
all TM proteins share certain characteristics !
! hydrophobicity - how strongly amino acid side chains are pushed out
The postsynaptic site
Chemical synaptic transmission has directionality
Two large classes of neurotransmitter receptors
Receptor proteins (us.
multimeric) that are themselves
The next 2 weeks of neuroscience
Dr. Duncan ODell (slides adapted from Dr. Cecile Fradins slides)
Diffusion & Electro-diffusion (week 1)
Wikipedia: Blausen 0315 Diffusion.png
RC circuits & c