Kaj Blennow, Mony J de Leon, Henrik Zetterberg
Alzheimers disease is the most common cause of dementia. Research advances have enabled detailed understanding
of the molecular pathogenesis of the hallmarks of the diseaseie, plaqu
The toxic A oligomer and Alzheimers
disease: an emperor in need of clothes
2012 Nature America, Inc. All rights reserved.
Iryna Benilova1,2, Eric Karran1 & Bart De Strooper1,2
The toxic Ab oligomer hypothesis has attracted considerable attenti
The case for rejecting the amyloid cascade hypothesis
2015 Nature America, Inc. All rights reserved.
Alzheimers disease (AD) is a biologically complex
neurodegenerative dementia. Nearly 20 years ago, with the
Hypothetical model of dynamic biomarkers of the
Alzheimers pathological cascade
Cliord R Jack Jr, David S Knopman, William J Jagust, Leslie M Shaw, Paul S Aisen, Michael W Weiner, Ronald C Petersen, John Q Trojanowski
Currently available evi
Application of triple immunohistochemistry to
characterize amyloid plaque-associated
in ammation in brains with Alzheimers disease
MR DAndrea, PA Reiser, NA Gumula, BM Hertzog, P Andrade-Gordon
The R.W. Johnson Pharmaceutical Research Insti
Neuroinammation in Alzheimers disease
Michael T Heneka, Monica J Carson, Joseph El Khoury, Gary E Landreth, Frederic Brosseron, Douglas L Feinstein, Andreas H Jacobs,
Tony Wyss-Coray, Javier Vitorica, Richard M Ransoho, Karl Herrup, Sally A Frautsc
Symptoms Severe Memory Impairment
Severe Brain Atrophy
Particular loss in temporal lobe
Longitudinal Structural Changes
fMRI in one 75 yo patient over 10 years starting at
cognitively normal baseline highligh
4501 Midterm I Study Guide
Describe ion distribution across the membrane, phases of the action potential and which ions
are moving at a given time.
What happens to the membrane potential when an AMPA receptor opens to allow Na+ entry?
When an NMDA recepto
Instructor: Holly M. Brothers, Ph.D., Department
Office Hour: Thursday 12:30-1:30PM, Townshend
Hall Room 26, *except, office hour Nov 3 will be
held Tues Nov 1st.
For questions: brothe