Jennifer Stanford, Ph.D.
Protein Modifications in the ER
Disulfide bond formation:
Left: Borrowed from Tom Rapoport. Right: Adapted from Figure 1, Bardwell, J.C.A. (2002) Disulfide Bond Formation, a
Race between FAD and Oxygen. Developmental Cell 3:758-60
Five lectures on intracellular protein transport!
1.! Not comprehensive!
2.! We will try to concentrate on:!
How were things gured out?!
What are the mechanisms? (forget about names!)!
!What is unknown? (cool projects for you to work on!)!
3.! Ask questio