Orthopaedic devices: Hip replacement
BiomaterialsClasses of Biomaterials
Were replacing both sides of
the joint. As for fixation, there
are two types. Originally, we
had cemented fixation, where
the cement acts as a grout and
is really an interfa
Solids are either amorphous or crystalline or mixture of both
Material Science: The Structure of Crystalline
Crystalline long range order exists; atoms are arranges in a regular repeated pattern
e.g. metals, ceramic, some polymers
What is a Polymeric Biomaterial?
BiomaterialsPolymeric Structures and Properties
What is a polymer?
The word is from Greek roots poly meaning many and
meros meaning parts .
Many scientists prefer the word macromolecule.
If one discounts the
Injury causes cell death, damage to extracellular matrix,
loss of vascularity.
Wound healing process involves the repair of the damage
and reconstruction of tissue.
Very important area for Regenerati
Organization of the bodys defenses
Non-specific defenses: no need to decipher pathogens identity.
Always present in the body.
- Physical barriers
- Interferons (Im infected!)
- Natural cell killers (NK ce
Mechanical Properties of Biomaterials
Why mechanical properties?
Need to design materials that will withstand applied
load and in-service uses for
Bridges for autos and people
Heart valve testing
ISSUES TO ADDRESS.
Cross-section of the gear from
steel (C diffusion)
How does diffusion occur?
Mass transport of one material into another by
Why is it an import
Inflammation is natural initial phase of healing process that occurs
after tissue damage.
Inflammatory process includes:
o removing cellular and tissue debris from the site of injury;
o destroying any foreign material, bacteria, or m
Blood coagulation body defense mechanism
Hemostasis - the cessation of blood loss from a damaged vessel.
Upon vessel injury, platelets adhere to macromolecules in
the sub-endothelial tissues and then aggregate to form the
primary hemostatic plug.
BiomaterialsProtein Surface Interactions
The study of protein adsorption to biomaterials represents
one of the major themes in biomaterials research over the past 3
Proteins are bioactive molecules that control and regu
BiomaterialsMaterials Science Atomic Bonding
Materials drive our society it characterize the stage of our civilization:
What is materials science?
Materials Science study structure-property relationships (as
Several years ago, great focus on the genome mapping the DNA
sequence of humans.
The Human Genome Project (HGP)
Primary goal: identifying and
mapping the approximately 20,000
25,000 genes of the human genome
from both a physi