Drugs Acting on the Autonomic
Nervous System
Introduction
The autonomic nervous system, along with the
endocrine system, regulates body functions.
The endocrine system sends signals to target tissue
Exercise and Sport Pharmacology
CHAPTER
4
zSympathomimetics
zHsieh Wen-Tsong
z
CASE
z Wayne is close to realizing his dream of being a
professional player in the National Hockey League
(NHL).
z He alr
ADSORPTIO
N
by
Pranoy Pratik Raul
1
Content
Definition
Cause
Classification
Isotherms
Applications
Only 12 slides
2
What is Adsorption?
Adsorption is a process
that occurs when a gas or
liquid solute
19. Cholinergics, anticholinergics
and anticholinesterases
PNS
Sensory nerves
(body-to-brain)
Motor nerves
(brain-to-body)
Motor nerves of the PNS
Somatic motor nerve system
Enteric system
Autonomic
CHOLINERGICS
(PARASYMPATHOMIMETICS)
Dr. Ragia M Hegazy, M.D.
Assistant professor of Clinical Toxicology
Autonomic Nervous System (ANS)
Autonomic:(In-voluntary)
Parasympathetic
Sympathetic
Neuro-trans
Therapeutics III
Level III (Phar 545)
M.B. Bolger
8/17/99
Cholinergic Receptors
Agonists and Antagonists
Objectives: At the end of the next four hours the student should:
1.
2.
3.
4.
be able to identi
BIMM118
Autonomic Nervous System
BIMM118
Autonomic Nervous System
Autonomic Nervous System
Ganglia close to the
innervated organs
Ganglia close to the
spinal column
Myelinated axons
Preganglionic
B. 8 Anticholinesterase drugs
a. Classify the anticholinesterase drugs in relation to mechanism of action.
anionic site of action
competitive inhibitors of binding of quaternary nitrogen of ACh
edroph
Section 1.5 Continuity
We've actually already defined what it means for a function to be continuous when we started
talking about limits.
Definition:
A function, f, is continuous at a number if:
lim f
Section 2.3 Basic Differentiation Rules
We do not always want to use the limit form of the definition of the derivative to find
derivatives (too painful). So, over the centuries, shortcut rules have b
Section 1.2 A Catalog of Essential Functions
Power Functions f(x) = xn where n is an integer
some examples include:
f x=x
D: ( , ) , R: ( ,)
2
3
f x=x
D: ( , ) , R: [ 0, )
f x = x
D: ( , ) , R: ( ,)
1
Section 1.1 Functions and Their Representations
Definition
A function f is a rule that assigns to each element x in a set A exactly one element, called
f(x), in a set B.
What does it really mean? It i
Section 1.4 Calculating Limits
First, the rules:
Suppose:
lim f x and lim g x exist.
xa
xa
Then:
Summation:
lim [ f x gx] = lim f x lim g x
Difference:
lim [ f x gx ] = lim f x lim g x
Constant over:
Section 2.2 The Derivative as a Function
Last time we looked at the derivative of a function at a particular value a and we evaluated:
f ' a = lim
h 0
f ahf a
h
Now, let's just think of a as being var
Section 2.4 Product and Quotient Rules
1. Product Rule.
If f and g are both differentiable:
d
[ f xg x ] = f x d g x d f x g x
dx
dx
dx
Alternatively, fg' = fg ' gf '
What I say to myself: 1st times t
Section 2.1 Derivatives and Rates of Change
How do we find an equation for any line? Up until now, we need slope and one point or we need two
points. (So, how can we find slope.)
What if we only know
Section 1.6 Limits Involving Infinity
We will be looking at asymptotes:
lim f x = L
lim f x =
xa
and
Special Vertical
x
Horizontal
When does this happen?
Notation:
Vertical:
lim f x = DNE
x a
lim f
Section 1.3 The Limit of a Function
(pg. 25) Definition
We write
lim f x = L and say,
x a
The limit of f(x), as x approaches a equals L
If we can make the values of f(x) arbitrarily close to L (as clo
29. A sh is removed from a contaminated lake. You determine that a particular toxin is present
in im cells at a concemration X = 15M ngfi. You place the sh in a tank full of clean water [X
= pgfL], an
23. The molecules helm are often moved into or out of cells during biological processes. Decide
whether or not theyr would be able to cross the Cell membrane lime-l]? without the help of a
membrane pr
Base your answers to questions 5 through T on the information below and on your knowledge of
biology: The illustration is of a Tasmanian devil suffering from facial canter.
(Source: http:mnaturecomf
2?. The relationship of structure to function is one of the major themes in biology. Describe the
structure of enzymes and then explain how the function of enzymes is related to the
structure.
Descrip
universe would not be increasing.
3?. Reduced organic compounds tend to contain stored energy in EH bonds. As a general rule,
the greater the number of [3H bonds, the greater the amount of potential e
31. According to the data, the mice at 1DC demonstrated greater oxygen consumption per gram
of tissue than did the mice at 25C. This is most like]? explained by which of the following
statements?
a.
The student predicted that the contractile vacuole would contract fewer times in one minute in a
solution that had a higher concentration of salt than that found in typical pond water.
25. This predic
In the experimental investigation. paramecia were placed in salt solutions of increasing osmolarity.
The rate at which the contractile vacuole contracted to pump out excess water was determined and
pl
b. What is the role of protein ldoase in this process?
II Protein ldnase is an enzyme that adds a phosphate group to a target
molecule from ATP.
or This results in the target molecule changing shape a
b. After making your hypothesis, you test it by measuring the toxin levels in the sh at
E.
various mes during its 10 days in the tank. You observe that the level oftoxin in the
sh drops from 1,5DU pgj
39. The evolution of photosvthesizing organiSms on Earth and the development of an
oxygen-rich environment led to a rapid diversication oflife. Explain why there is an
evolutionaryr advantage to an or
11. Based on your knowledge of the polarity of water molecules, the solute molecule depicted
in the model below is most likely.
a. positively charged. a w
b. negatively charged. ,
c. without charge. ?