Questions, Comments re Dr. Stynes Talk?
OR, the Readings?
1) Review of Normal Glucose Regulation
2) Review of Diabetes
3) LAST Quiz (#8)
Todays Broad Concept:
What is Meant by Tight Control?
50 years ago (1960s) tight contr
Is Halfway Done!
Is EXB 104L Working ?
24 N / cm2
Orientation to Our Progress in EXB 104L
No Labs are Harder than Lab #3 (completed!)
This Week (Resting Metabolic Rate) is a Catch Your Breath Lab (Ha!)
Next Monday, April 25th:
Dennis M. Styne, MD
Yo Che Dehe Chair Chair
and Professor of Pediatrics
University of California Davis Medical Center
The Canary in the Coal Mine
The Canary is Suffocating
The Atmosphere is Toxic
Do We Ha
Orientation to Our Progress in Spring :
This is the Last Week (only 3 days) of Classes
There is NO quiz this week
(I have posted Anonymous Q8 Results on Box)
This Friday, June 3rd is a Dead Day
Our Final Exam in EXB 117 is Monday, June 6th, 8-
Course Evaluations Online?
Alternate vs. Regular Final
Talk a bit about the Final Exam
Continue Pruning the Diagnostic Tree
Using Two final case studies
Administration and Finals Week
Last Call on Quizzes
phototransduction are graded potential
rhodopsin integrated to disc membrane
in dark not activated
high amount of GMP in dark
cGMP bind to Na gated channel (ligand), let Na in
release of neurotransmitter onto bipolar cells
transducing serve as G protein pathway, activates phostodieseterase which
catalyzes cGMP to GMP, no bind to Na gated channel
reduces amount of neurotransmitter thats being released by photo-transducing cells
A Word of Cheer.
From Your Course Cheerleader.
Regulation w/ Ex
Motor Learning & Control
May 23rd MIDTERM #2
Monday, May 30th
(abstract #8 due; work
Collect Q1-How would you calculate
sample rate for temp?
Health and Safety consent
Lab Report Expectations
Quizzes and Procedure outlines
Instrumentation Lab Review?
How to Induce and Maintain General Anesthesia in NPB 111L
Some thoughts on the general anesthetic used in this course:
We will be using a schedule II drug called Sodium Pentobarbital which we
will administer intravenously. Pentobarbital belongs to a group
Instrumentation Problem Set
Intro and Calibration
1. The signals that you will record in this class will emerge from the
chicken and be expressed in terms of natural units (e.g. blood
pressure in terms of mmHg). These signals are eventually converted
Local and Autonomic Control of Cardiovascular Activity
1. To demonstrate the effects of autonomic agonists on heart rate and
2. To demonstrate the effects of local control (nitric oxide) on blood
pressure and heart rate.
Calibrating Transducers and Recording Signals
What is Calibrating?
The Biopac box contains 4 digital amplifiers, each one capable of
receiving one of the signals you want to record from your subject. For
example in the third exercise on muscle physiology
Physiological Instrumentation and Data Acquisition
1. To familiarize yourself with the data acquisition hardware and
2. To understand the nature and flow of recorded signals as they are
measured and displayed.
3. To learn how to accu