Cell Biology M140
Tues and Thurs 11:00-12:20 Botany 325
Text: Molecular Cell Biology (7th Edition) Lodish et al .
Dr. Michael Grunstein
April 1, 3, 8, 10, 15 (no class), 17
Chromosome structure and gene regulation (Ch. 6 and
Cytoskeleton: a network of fibers
microfilaments (7-9 nm), intermediate filaments (10 nm), microtubules (24 nm) (polymers)
dynamic can be deconstructed and rebuilt (polymerization/depolymerization)
Microfilaments are ac
M140-Signal Transduction (2014)
350C BSRB (825-1251)
Cells must sense and respond to environmental cues:
moving toward nutrient sources and away from toxins
Cells need to communicate with other cells for coordinate
What is an example of "juxtacrine" signaling between cells?
How can we determine the level of non-specific ligand binding to cells?
Can a transmembrane segment include charged amino acids?
What is cooperative binding?
Why might cells recycle vs.
1. (A) Describe and explain two functional roles of APC in the control of mitotic
events. (12 pts)
1) Segregation of sister chromatids: APC associates with cofactor Cdc20 to form
an E3 ligase complex that promotes the polyubiquitination and degradation of