symbiosis is an association between two or more species. We can separate into three categories. Parasites usually don't kill their hosts. It's usually pretty ancient. The more ancient it is the more beneficial it is. Aphids provide essential amino
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Changing Surface Antigens
green bc different antigen = VSG, allows it to outrun the immune system
procyclin~LPG, interacts w intestinal tract
Trichomonas vaginalis does not have a typical mitochondria
but instead has an unusual organelle: the hydrogenosome
Facultative anaerobe, also true for Giardia
This means they do not use oxygen for
Lack peroxisomes an
Leading causes of disability life years (DALYs) due to
infectious and parasitic disease
December 2nd - 4:30-6
children under 5?
Contaminated water is a source of Giardia & Entamoeba infection.
Infection is common in developing countri
Lecture 3 Leishmania (2)
Kinetoplastid Protozoa (Leishmania spp.)
as a Developmental Model
1. development of synthetic
monophyletic group, mostly parasitic
related to ciliates & dinoflagellates
Alveolata - all have flattened vesiclelike structures-called cortical
alveolae-just underneath the plasma
Seven species infect humans
Toxoplasma II the Inner Membrane
Complex and Endodyogeny
A brief reminder from last time.
Toxoplasma is an obligate intracellular parasite
Infection via cysts from contaminated undercooked me
The neural basis of parasitic behaviors
Elissa Hallem, Ph.D.
Department of Microbiology, Immunology, and Molecular Genetics
University of California, Los Angeles
MIMG 168, 10-27-16
Office hour and contact info
Blood sucking bugs. They were called barbeiros becaue they bit around the mouth when they were asleep. Sometimes there's 1000s of bugs. Do these bugs transmit a disease? He found a lot of flagellates known as trypanosomes
African Trypanosome - Sleeping Sickness
Question from discussion:
Who was the first to find out there could be another vector for disease, Manson or Bruci?
Trypanosomes in fish or frogs are very beautiful but not well studied because we can't culture them
For S. America, they've gotten rid of it all except Bolivia.
People didnt' know there were sexual phase. They were clonal, diploid. Later they started using classical genetics. They got evidence there was gene recombinance in the tsetse fly. It's kind of
VSG covers the parasite. there is spontaneous mutations and change. There is a second antibody. the way the parasites change from one antigen to another but the most common mech is gene conversion. 1 where there is .
Recent in evolution, VSG wa
This is called kinetoplast DNA. it's called the kDNA nucleoid body. There's a single . It's very highly flagellated. Lemme just tell you how these cells divide. The first thing that happens is tha tyou start seeing the kinetoplast divides first so you see
Midterm will be like the sample questions on the website. Covers up until this Thursday. The midterm is on Tuesday. Q&A Review Monday Y 6:30PM to 8:30PM CS 76 TA-led
Only uridienes are inserted, sometimes deleted. They are inserted and deleted
They7 got the gene for the color and made it a trans gene and transfected the petunia but got these variegated patches petunia. Baulcombe is highly under appreciated. A lot of times people in the animal field don't read the plant literature. when they dis
we're talking about the ability to create encystation excystation in the laboratory. It gives an observation of a switching of the surface protein. The virulence coating. It switches encystation and excystation. They had started off a populationti
Why is it good to be intracellular?
Easy to spread through the body
Hidden from host immune system
Nutrient rich area
Why is it hard to make a malaria vaccine?
High rate of antigenic variation mutatio
MIMG 168 - Molecular Parasitology
Prof. Patricia Johnson
Prof. David Campbell
Dr. Michelle Castelletto
Prof. Elissa Hallem
Prof. Peter Bradley
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2 forms of parasite
- deposited in
develops into left
Unicellular Parasites are Highly Divergent
Yeast & Animals
4 clades have major human parasites
lots of diversity!
Trichomonas & Giardia
Next 4 lectures will cover: