Branching that occurs is differentiation.
Determination: Point at which cells begin to specify a different pathway
o Determination leads to COMMITMENT
o Commitment will never be before determination
Commitment: when it reaches commitment, the c
Exams are given only at the times listed in the syllabus. If your schedule does
not permit you to attend these exams, then you should not enroll in this course.
Alternative scheduling of the exams can occur for the following rea
Lecture 1 Development of Musculoskeletal Structures
3 Components of Development
Only 1 of the 3 components needs to be occurring to say it is developing.
Growth (in size)
Differentiation (acquisition of specialized traits)
Morphogenesis (leads to more spe
We ended at limb bud development Recap:
Morphogenic events and Growth (cells are proliferating)
Cells of myotome migrated away from somites toward periphery to give rise to limb buds
Regulated by Neural Tube (forms spinal chord)
Ventral to n
Look at events for transition from simple mononucleated muscle cell into highly structuralized multi
nucleated muscle fibers
How do the fibers become multinucleated? (tested by Mintz and Baker in vitro)
Approach: start with embryonic muscle, put