Impacts of Polarity Protic solvents that contain OH or NHx groups are generally poor solvents for Sn2 rxns b/c the solvent molecules arrange in a way around the nucleophile that they form a solvent cage Decrease the ground-state energy of the nucle
1. Mix .2g tetraphenylcyclopentadienone, .1g of anthranilic acid, 2.5mL 1,2dimethoxyethane in a 10mL round bottom flask. 2. Clamp the flask 3. Attach air condenser. 4. Dissolve .15mL of isopentyl nitrite (isoamyl nitrite) in 1 mL of 1,2-dimethoxyetha
Exp 5 Charge a 5mL conical vial with ~.2g of dibenzyl ketone (d=1.068 g/mL), .2g of Benzil, and 1.5 mL of absolute ethanol. Insert a spin vane point down will keep the solid in suspension and usually avoids bumping Attach an air-condenser Plac
Exp 3 Procedure 1. Dissolve 150 mg (.15g) of camphor in 1mL of methanol in 25mL Erlenmeyer flask. 2. CAUTIOUSLY add .04 g of sodium borohydride every 30 seconds to the solution in the flask. a. This ensures complete reduction of camphor. This way the
Are Alkyl flurides good substrates: good leaving groups=large, polarize, weak bases
As you go down, in LG, best (I)- F is not a good leaving group
Sn1 LG leaves, why does it leave?
Bc solvent is pulling on itlarger, more polarizable, easier to pull off, a