Lecture 15 - Viral Virulence
- animal models!
human viruses in animals!
animal viruses that resemble human infection!
IFN alpha/beta controls poliovirus tropism!
- Viral virulence!
capacity of a virus to cause disease in a host!
virulent vs avirulent
Lecture 12 - Infection Basics
- The nature of host-parasite interactions!
the viral genome must establish itself in a host population to endure!
- We live and prosper in a literal cloud of viruses!
most infections have no consequence!
if we do get infe
Lecture 11 - Assembly
- All virions complete a common set of assembly reactions!
formation of individual structural units of the protein shell from one or several viral
Assembly of the protein shell by appropriate and sometimes variable, inter
Lecture 16 - Acute Infections
- General Patterns of infection!
- Incubation period!
initial period before symptoms of disease are obvious!
viral genomes are replicating!
host is responding (cytokines with global effects)!
- fever, malaise, aches, pains
Lecture 10 - Translation
- Retroviruses go from single +RNA to -DNA to +-DNA to +mRNA!
Hepatitis B virus broken +- DNA to +-DNA to +mRNA!
Reovirus goes double stranded +-RNA to +mRNA!
Inuenza virus VSV goes single -RNA to +mRNA!
Poliovirus Sindbis vir
Saturday, February 15, 2014
- What is a virus?!
Infect all living things!
eat and breathe billions of virions regularly!
carry viral genomes as part of our genetic material!
More than 10^30 bacteriophage particles in the worlds w
Lecture 13 - Intrinsic and Innate defenses
- RNA interference!
plant and invertebrate cells!
mammals - present or not needed?!
- Viral regulators of apoptosis!
- Innate immune system!
activated within minutes to hours after infection!
1. What is transcription? What are the generic steps in this process?
Transcription: The process by which messenger RNA is synthesized from a DNA
template resulting in the transfer of genetic information from the DNA molecule to
the messenger RN