a. Chronic disorder of the central nervous system characterized by the brain's
inability to control sleep-wake cycles
b. Uncontrollable sleep episodes lasting from a few seconds to a few minutes
c. Greek origin
A very complex amalgam of physiological and behavioral processes
Lack of response to outside stimuli
o perceptual wall between conscious mind and outside world
- State alternating with waking
Class 4: Prof. Dinges Lecture 3 31 Jan. 2013 Circadian rhythms: Physiological systems, hormones, sleep
Experimental paradigms for establishing the presence and relative Influence of endogenous circadian rhythmicity:
-free-run and spontaneous internal desy
Class 5: Prof. Dinges Lecture 4 7 Feb. 2013
Why study circadian rhythms in animals?
Circadian clocks in Drosophila Melanogaster and rodents.
What is the mechanism of the interaction of the circadian clock
and the homeostatic drive for sleep?
REVIEW FOR MI
Class 8 Lecture 5 28 February, 2013 Sleep phenomenology-from phylogeny to ontogeny.
Sleep: Behavioral and electrophysiological definitions. How do you know whether/when an organism is sleeping? Sleep and evolution. The increasing hypersynchrony of nonREM
Class 9 Lecture 6 14 March 2013
Neurobiology of Sleep and Waking - What keeps us
awake? What puts us to sleep?
Ascending reticular activation.
Basal forebrain (adenosine modulated cholinergic neurons)
Nucleus of the solitary tract.
Class 10 Lecture 7 21 March 2013
Andrea Spaeth (eating & sleep)
Read Basics of SleepChapters 1-7 and 11-17b
The Obesity Epidemic
Sleep duration and Energy Balance
Class 11 Lecture 8 28 March 2013 Consequences of Human Sleep Deprivation Sleep propensity as measured by sleep latency tests. Sleepiness and its neurobehavioral consequences. Sleep deprivation and sleep debt. Wake state instability. Drowsy driving and fal
Class 2: Prof. Dinges Lecture 1 17 Jan. 2013
Origins, measurements and meanings of biological rhythms
Discussion of biological rhythms & sleep - Are humans unique among animals?
What do plants and people have in common?
Some historical firsts in establish
ARCHITECTURE AND PHYSIOLOGY OF SLEEP
Recording of electrical activity on the scalp produced by firing of neurons in the brain
Amplitude and frequency changes between wakefulness and sleep stages
Can compare activity of different brain parts
CHEMICALS IMPLICATED IN WAKING
- Catechol and amino group (derived from tyrosine)
- Drugs that increase catecholamines cause intense and prolonged arousal and cortical
o Can be done by increasing production or inhibiting reuptake
- Circadian clock
o Awake at the same time each day
o Bright light during desired daytime hours
- Homeostatic Sleep Drive
o Go to bed only when sleepy
- Nap during the late morning or early afternoon; never too close to be
December 9, 2011
Dr. Lee Brooks
Imagine unexpectedly falling and collapsing into deep sleep while giving a presentation.
Imagine laughing at a funny joke then suddenly not being able to move. Imagine seeing bright
flashes of li
Lecture 1 Notes What if we had no moon? Earth mark 2 earth post the planetary impact that created the moon The moon is a 4th the size of the earth, which is unique (with the exception of Pluto). 3 theories of the moon don't work capturing the moon in orbi
Lecture 3 Notes Night shift work (know this) Europe = 18.8% (Boisard et al., 2002) u U.S. estimates = 16.8% (Beers et al., 2000) u MITAS sample = 26.1% (Drake et al., 2004) Christopher Drake, Ph.D. Rotating shifts in past 2 weeks = 13.4% of working popula
Section 2Lecture 4 Notes Left side of red curve= life style Right side = poverty The more you pay ppl the less they'll sleep Work and travel time cause less sleep and control wake up time Bed time controlled by prime time television circadian timing syste
The Giant Impact hypothesis - the now-dominant scientific hypothesis for the
formation of the Moon, which is thought to have formed as a result of a collision between
the young Earth and a Mars-sized body that is sometimes called Theia or Orpheus.