Immunity Mediated by
B Cells and Antibodies
Focus of Chapter 9
How Antibodies Clear Infection
Antibodies recruit destructive, nonspecific immune system
components to the infecting pathogen
Antibodies bind and link the pathogen to effec
T Cell-Mediated Immunity
T Cell-Mediated Immunity
1. Activation of nave T cells on encounter with antigen
What happens when nave T cell encounters its
specific antigen for the first time and is stimulated to
differentiate into an effector cel
The Development Of B-lymphocytes
Chapter 6 60 billion new B-cells/day
The development of B cells in the bone marrow
-1st of the 6 broad stages in the life cycle of B cells
Selection and further development of the B-cell
Exam 3 Study Guide
Chapters 5 and 6
1. BCR (B cell receptor) and TCR (T cell receptor), how are they created and where in the body are
Somatic recombination, equals sequence variability in V regions. After activation, thei
PCB 3233 Exam 4
1) Development (maturation) of T cells, where does it take place
2) What gene segments are rearranged for the alpha and beta chains?
Alpha: V & J Beta: V, D, and J
3) Are the RAG genes used in the rearrangement?
Antibody Structure And The
Generation Of B-cell Diversity
The Structural Basis Of Antibody Diversity
Antibodies And Antigens
Five chemically and physically distinct classes of antibodies (IgG, IgA,
IgM, IgD, IgE)
Bind with hig
Innate Immunity The induced
Three Lines of Defense
Induced Innate Immune Response
Once the pathogen has breached the physical
barriers and outrun the initial response the induced
innate response takes place.
Elements of the Immune system
and their Roles in Defense
Immunology is the study of physiological mechanisms that
are used to defend the body from invasion by foreign or
In response to diseases caused by infect
Three Defense Categories
Physical barriers, Fixed or hard-wired mechanisms
Innate immune mechanisms called into action by
the initial innate immune response that take hours
to days to work
Adaptive immune response
Maturation takes place in the thymus.
Activation takes place in the secondary lymphoid tissues.
Uses RAG 1 and RAG 2 for somatic recombination.
Does not rearrange BCR genes.
Rearranges TCR genes
Alpha = light
Alpha includes V and J only
Dendritic cells are the only presenting cells that activate T cells.
Professional presenting cells are also macrophages and b cells. These will activate
TH1 = macrophages
TH2 and T f = B cells.
Activation of naive T cell in secondary lymph
CD4 and CD8 are co receptors
CD4 can become TH1, TH2, TH17, T reg, and T foc.
CD8 can become cytokines lymphocytes.
Somatic recombination = alpha and beta genes rearranged.
Race between beta and gamma delta. Beta usually wins (rearrange V, D, and J). Put