Solution to Homework Assignment 2
1. (12 pts) In a small clinical trial, permuted block randomization was used to assign
one of two treatments (A or B) to six patients. Two blocks are chosen; the first block
size was four (two A's and two B's chosen at ra

PHC 6020 Homework Assignment 4
Due Tuesday November 29, 2011
(Please show all your work, i.e. the steps that are necessary to reach your results.)
1. (16 pts) In the table below are the results of a small clinical trial comparing two
treatments. The endpo

PHC 6020 Homework Assignment 1
Due 1:55pm Tuesday September 13, 2011
(Please show all your work, i.e. the steps that are necessary to reach your results.)
1. (30 pts) Suppose in a population 30% of all individuals live in areas which are
considered heavil

PHC 6020 Homework Assignment 2
Due Tuesday October 11, 2011
(Please show all your work, i.e. the steps that are necessary to reach your results.)
1. (12 pts) In a small clinical trial, permuted block randomization was used to assign
one of two treatments

PHC 6020 Homework Assignment 3
Due Thursday November 3, 2011
(Please show all your work, i.e. the steps that are necessary to reach your results.)
1. (20 pts) In class we derived the sample size formula for comparing two treatments
which produce binary re

Solution to Homework Assignment 3
1
Question 1
a. Since g (p) = cfw_p(1 p)1/3 , using delta method, we have that
V arcfw_g (p) = cfw_g ( )2 V ar(p) = cfw_pi(1 )2/3
cfw_ (1 )
cfw_p(1 p)1/3
=
.
n
n
b. From part a., we have that
a
g (p1 ) N
g (1 ),
cfw_1 (1

Solution to Homework Assignment 4
1
Question 1
a. Let Ui = min(Ti , Ci ) be the observed time, i = I (Ti Ci ) be the failure indicator and n(Ui ) be
the number of patients at risk at time Ui for the ith individual, where Ti and Ci are the underlying
survi

University of Florida
College of Public Health and Health Professions and College of Medicine
PHC 6020: Clinical Trials Methods
Fall 2011
Primary Instructor:
Xiaomin Lu, Ph.D.
Assistant Professor, Department of Biostatistics
College of Public Health and H

University of Florida
College of Public Health and Health Professions and College of Medicine
PHC 6020: Clinical Trials Methods
Fall 2011
Primary Instructor:
Xiaomin Lu, Ph.D.
Assistant Professor, Department of Biostatistics
College of Public Health and H