Welcome to Survey of Biochemistry (BIOC 3653), Spring 2014
Please read the course syllabus (see D2L).
Excerpts from the syllabus
1. General information about this course
Prerequisites. You need to have already taken a semester of or
Lecture 2-Proteins (Chapter 2)
Proteins are linear polymers built from monomers of amino acids.
There are 20 different types of (standard) amino acids,
in all proteins, in all life forms.
A Generic Amino Acid
R = distinctive side chain
Lecture 3-Techniques (Chapter 3)
Techniques of modern biochemistry include:
A.Purify a specific protein from cells.
B. Detect specific proteins with antibodies.
C. Identify proteins by mass spectrometry.
D. Determine the three-dimensional structure of a p
Lecture 4-NucleicAcids (Chapter 4)
Genetic flow of information:
The Central Dogma of Molecular Biology
DNA information storage (with mutational drift)
RNA information mes
CHAPTER 8: ENZYMES Basic Concepts & Kinetics
to hexokinase induces
a conformational change
in the active site of
Enzymes are named by the reaction that they catalyze,
followed by ase.
Classes of enzymes:
Chapter 30: Translation
(nucleic acid sequence)
N-Ala-Ala-Thr-Arg-Ser (amino acid sequence)
The ribosome catalyzes peptide bond formation between two
different amino acids.
The ribosome deprotonates the amino group of one amino acid
CHAPTER 7: GLOBINS Prototypes of Proteins in Action
(from Sperm Whale)
(from Horse Heart)
First known protein structure
(John Kendrew, 1950s)
Second known protein structure
in bacteria and
2. RNA splicing
3. Catalytic RNA
in bacteria and
2. Cellular sorting
of proteins in
Control of gene expression