Female vs male gametogenesis
Seminiferous tubules cross sections
Spermatogenesis is divided in three distinct phases:
Spermatogonial phase (MITOTIC AMPLIFICATION)
A dark spermatogonia, A pale spermatogonia, B spermatogonia
Microarray and Sequencing
Paolo Fortina, MD
Discovery of DNA Structure
Sanger Sequencing by F. Sanger
PCR by K. Mullis
Human Genome Project
1993 Development of pyrosequencing
454 Life Sciences Fou
Methods used in histology
Light microscopy or optical
Electron microscopy (EM) Transmission EM and Scanning EM
Atomic force microscopy (AFM)
Other methods: some of the important ones
Radiosotopic methods: can be traced bec
KNOW - !
- technologies for investigating!
- microarrays both for DNA and RNA !
CFTR 7q36, 27 exons, >1K mutations!
Respiratory apparatus (dense mucus, reduced transport of parti
- Survival (no response to death signals)!
- Angiogenesis (after a while they can recruit blood vessels that will bring nourishment and get
rid of waste)!
- Invasion (they will be able to stay alive and proli
Tyrosine Kinase Receptors!
Growth factors signal through receptor tyrosine kinases (RTK)!
These receptors have an enzymatic activity - on extracellular side they have receptor activity,
while on the cytosolic side they have enzy
Cells integrate the many signals that they receive in deciding whether to survive, grow and
divide (proliferate), differentiate, or die (apoptosis)!
We say that these signals are very important in order to maintain h
bio nal (test 3) ashcards | Quizlet
bio final (test 3)
5/5/14, 3:26 PM
Created by MrMagic32
This set has 50 terms
Which of the following statements about
metabolic pathways is FALSE?
a. the product of one reaction becomes
Leukemias and Lymphomas!
Breast and Ovarian Cancer!
Circulating free DNA (cfDNA)!
Circulating tumor cell (CTC)!
Genes in Tumorigenesis!
- Oncogenes = gain of function.!