- Different TLRs recruit different adapter proteins to the TIR domain.
Different adapter proteins lead to different events pathways include: NfKb transcription factor activation, Interferon regulating factor (IRF)
pathways, MAP kinase pathway downstream
1. Hematopoietin (class 1): gP 130 receptor subfamily. Critically important. Ligand-specific dimers or
trimers are expressed with gp;130 subunit. * Receptor for monomeric and dimeric cytokines. Signaling
path are similar i
Immunology chapter 7
The puzzle of immunoglobulin gene structure2-4
Antibodies can be produced for an enormous variety of different
specific antigens (107-1011 different specificities)
- But how can a limited amount of DNA genetic information
The complement system1-7
A group of serum proteins circulating in inactive form. Once activated
multiple possible outcomes: target cell membrane lysis, chemotasis,
opsonization to enhance phagocytosis.
A group of serum proteins circulat