BME 144. Quantitative Physiology
Problem Set 1 Solution
Spring 2012
Due: Jan. 24
1. Use the Goldman equation to assess how the sodium and potassium
permeability affect the membrane potential. Use a ratio of permeability values
of PK:PNa:PCl of 1:0.05:0.45
BME 144. Quantitative Physiology
Spring 2012
SOLUTION Sample Exam Questions
1. (8 points) Explain why the speed of the action potential in skeletal muscle is
less than in nerves.
Muscle is not myelinated
Muscle is much thicker and current ravels along sur
Name
BME 144. Quantitative Physiology
Sample Exam
Spring 2012
SOLUTION
1. (8 points) An examination of a young child suffering from severe diarrhea indicated
that the blood pH was 7.3 and the arterial pCO2 was 40 mm Hg. Identify which of the
condi
BME 144 Quantitative Physiology
Spring 2012
Problem Set 9
SOLUTION
1. Figure 28-12 shows the effect of antidiuretic hormone on plasma sodium
concentration for different levels of Na+ uptake for the dog. Assume that the
same trends hold for humans and cons
BME 144 Quantitative Physiology
Spring 2012
Problem Set 7 SOLUTION
Due: April 3, 2012
1. HbO2 dissociation curve. (2.5 points per section)
Using the attached Gui and Figure file, estimate the value of P50 and explain
the effect of the following on the HbO
BME 144 Quantitative Physiology
Spring 2012
Problem Set 6
Due: March 27, 2012
1. (20 points) In this problem you are asked to perform a mass balance to derive
the relation for FRC, functional residual capacity. The measurement is
performed with a spiromet
BME 144 Quantitative Physiology
Spring 2012
Problem Set 4
SOLUTION
1. Describe the path an action potential would take in a healthy heart starting at
the SA node. What feature of the pathway accounts for the delay between atrial
and ventricular contractio
BME 144 Quantitative Physiology
Spring 2012
Problem Set 5
SOLUTION
Due: March 15, 2012
1. (10 points) Filtration in normal tissue. Consider a tissue with the following
conditions.
Pcap = 30 mm Hg
Mean capillary pressure
Ptissue = 0 mm Hg
= 27 mm Hg
a. Det
BME 144 Quantitative Physiology
Spring 2012
Problem Set 3 Muscle Physiology
SOULTION
1. (10 points) Consider the Hill model:
(T+a)v= b(T0-T)
in which a and b are constants determined from data; T0 and T represent the
tension (or contractile force) in the
BME 144. Quantitative Physiology
Spring 2012
Problem Set 2
SOLUTION
Analyzing the minimal model
Insulin (I or y(1) in the MATLAB model) is rapidly released from the beta cells when the glucose level
rises above a set point value, GT.
dI ( G ( t ) GT )
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BME 144. Quantitative Physiology
Final Exam
Spring 2012
April 30, 2012
1. (6 points) When placed in the following solutions do red cells shrink, swell, or undergo
no change in size. Briefly state the reason for your answer.
a. 0.15 M NaCl - No
BME 144. Quantitative Physiology
Exam 1
Spring 2012
SOLUTION
1. (3 points) Choose a statement that explains why most of the cells in the brain
do not increase glucose uptake after exposure to insulin.
(a) Brain cells do not need glucose to meet their ener