1. Name the four basic types of animal tissues. (Epithelium)
2. What are the major functions of the extracellular matrix? List two components of
What is the definitive proof for a cell sample to be classified as HSC?
Ability to produce a long-lasting multilineage clone of blood cells in
What makes the isolation of HSC so challenging?
No one specific marker has been found.
Rare. Even in a h
Cell Science at a Glance
The formation of
SeYeon Chung and Deborah J.
Department of Cell Biology, The Johns Hopkins
University School of Medicine, 725 N. Wolfe Street,
Baltimore, MD 21296, USA
*Author for correspondence
Wednesday Oct 9, 2013
What was done?
Creation of a
What are some engineering tools that were used in creating the replacement jaw?
Discussion Wed, Dec 16, 2013
Paper: Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle
McCain et al, PNAS 2012
This paper is concerned with how mechanical stresses are distributed over the cell body and
junctions. Where do these
Matrix Elasticity Directs
Stem Cell Lineage
Adam J. Engler, Shamik Sen, H. Lee Sweeney, and Dennis E. Discher
University of Pennsylvania, Philadelphia, PA
Cell 126 677-689, August 25, 2006
Stem cell differentiation
Cell lineage specif
Strategy for the Selection of
Scaffolds for Tissue Engineering
Eugene Bell, PhD.
Tissue Engineering Vol. 1, No. 2, 1995.
As we begin to think about materials for building prostheses to replace diseased, injured, and genetically or
Stem Cell Basics
About this document
This primer on stem cells is intended for anyone who wishes to learn more about the
biological properties of stem cells, the important questions about stem cells that are the
focus of scientific research, and the poten
Homework Set 1
Due Thursday, October 17, 2013
Please complete on a separate sheet of paper, with any necessary explanations or
calculations displayed. Turn in with name and student number labeled before
lecture for full credit.
1) (7 p
Introduc)on to Cell and Tissue
Objec)ves of cell and )ssue engineering
Morphogenesis and Tissue development
Cell sources: Stem Cells and CommiGed Cells
Due Thursday, October 24, 2013
Focal adhesion kinase (FAK) is known to localize
to sites of integrin clustering and regulate the
formation and turnover of focal adhesions. In an
attempt to understand the role of FAK in cell
Two main components
Cells and Extracellular Matrix
ProkaryoDc cells and EukaryoDc cells
Thin layer of lipid and protein m
BENG 166A HOMEWORK 4
1) In this simple diffusion schematic, is a particle at position P
and time t more likely to move left or right?
2) In the paper OXYGEN DIFFUSION THROUGH NATURAL EXTRACELLULAR MATRICES found at
Due Thursday 11/21
1. Explain why cells in suspension assume a spherical shape based on the
discussion in the paper. What causes cell surface tension and how would you
define it in physics perspective? [Hint: Refer to Cell surface mec
Homework due on Dec. 3
Identify a tissue/organ that you want to engineer and state the targeted
properties of this tissue. If your target is a tissue, state the dimensions of the
Describe the cells, scaffold, scaffold fabrication, and cul
Cooperative coupling of cell-matrix and
cellcell adhesions in cardiac muscle
Megan L. McCaina, Hyungsuk Leea,1, Yvonne Aratyn-Schausa, Andr G. Klberb, and Kevin Kit Parkera,2
Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering