Experiments done to determine the role of K+ in generating resting membrane potential. Experiment: used the giant axon of squid (100x larger in diameter than some axons in mammalian species). Table of ion concentration: overall concentration of ions in
3 Na+ ions Energy input of ATP causes pump to change shape & flip around, letting Na+ out and bringing 2 K+ in.
Myelin allows AP to propagate faster than it would in an unmyelinated axon. Current is continually leaking out, so need more Na+
Synaptic vesicle cycle
transitions between transmitter being loaded to vesicles, being mobilized, docking & fusing w/ synaptic membrane, release of NT, reconstitution of vesicle structure, and refilled w/ NT.
enzyme come together to synthesi