We have described cancer as a disease in which cells have come to ignore the fundamental
rules governing the normal behavior of cells. What are some of these rules and how do
cancer cells violate them?
growth signals for proliferation - cancer cells can
What are G.E.F.s and G.A.P.s and how do they contribute to efficient growth signal
transduction? Do they qualify as proto-oncogenes? Do they qualify as tumor suppressor
Proteins that regulate Ras activity: GEF and GAP
GAP is a negative reg
What experimental strategy can be used to isolate human oncogenes? How did Robert
Weinberg use this type of strategy to isolate the first human oncogene?
Chemically transformed cells transferred to recipient cells in broken fragments
Focus chosen and DN