name:_ student ID:_ Genetics L311 final exam December 19, 2008 Directions: Please read each question carefully. Answer questions as concisely as possible. Excessively long answers, particularly if they include any inaccuracies, may result in deduction of
Problem set 2, Fall, 2010 student name: 8 points total 1. Diagram anaphase of mitosis for a diploid organism that contains 2 pairs C B AB c a chromosomes 1 long and 1 short.
2. Diagram metaphase of mitosis for a haploid organism that contains 2 chromosom
Problem set 1, Fall, 2010 student name: 8 points total Note: Please show your work and define your symbols clearly. 1. You roll a sixsided dice four times. a) What is the probability of rolling four sixes?
b) What is the probability of rolling no 1's in f
Problem Set 6, Fall, 2010 Name: 8 points total 1. You have recently discovered a new species of poisonous chimpanzees, M. tuae. Some of the individuals are hyperactive and run into tree branches at a high frequency. This tendency toward hyperactivity and
name:_ student ID:_ Genetics L311 final exam December 18, 2009 Directions: Please read each question carefully. Answer questions as concisely as possible. Excessively long answers, particularly if they include any inaccuracies, may result in deduction of
Lecture 13 Genetic mapping I. Genetic mapping A. genetic map B. map unit 1. map unit = 1/2(# crossovers between markers) 2. 1 map unit = 1% recombination expressed as map units or centiMorgans C. frequency proportional to distance between genes
Lecture 14 Mitotic recombination I. Double cross over may occur in multiple ways
A. No cross over:
Single cross over:
C. Twostrand double:
D. Fourstrand double: E. Threestrand doubles:
II. Mitotic "mistake" can cause unusual tissues 1
A. mitotic nond
Lecture 15 epigenetics I. Some genetic effects are not mediated by changes in DNA sequence A. epigenetics 1. can be mediated by protein expression 2. often mediated by DNA/histone modification
3. stably maintained through cell division II. Examples of epi
Lecture 16 gene mutations I. Gene mutations A. Change from wild type 1. forward mutation
2. reverse mutation (reversion)
B. Types mutations 1. basepair substitutions a. at DNA level i. transition
b. at pr
Lecture 17 Gene mutations; mechanisms and repair I. Spontaneous mutations A. result from several sources 1. errors of replication a. DNA polymerase can slip
b. other errors may occur during replication 2. spontaneous lesions a. depurination
Lecture 18 Chromosome Structure
I. So what is a chromosome? A. composed of chromatin DNA + protein; forms stable, ordered structure 1. 2. II. Genomes a brief overview A. chromosome number can vary greatly B. genome size
Genome Virus SV40 Herpes s
Lecture 19 Chromosome structure 2 I. centromere A. Region of chromosome that associates with spindle fibers
B. Terms 1. kinetochore 2. two types of centromeres: holocentric localized centromere C. chromosomes are characterized by centromere loc
Lecture 20 Chromosomal abnormalities structural I. Types of abnormalities A. deletion B. duplication C. inversion 1. paracentric 2. pericentric D. reciprocal translocation 1. Robertsonian translocation special type of translocation that fuses 2 acrocentri
Lecture 12 Genetic mapping I. Genetic mapping A. genetic map B. map unit 1. map unit = 1/2(# crossovers between markers) 2. 1 map unit = 1% recombination expressed as map units or centiMorgans C. frequency proportional to distance between genes
Lecture 11 Linkage Mapping/Recombination I. Discovery of linkage A. Unusual results from cross: cross P/pL/l X P/p L/l (Note: this P is different from P we've encountered previously) P=purple p = red L = long pollen l = round pollen Phen (gen) observed ex
Lecture 2 Mendelian genetics I. Blending? A. predominant theory during 19th century 1. germ cells contained sample of essences from each somatic cell 2. problem: clearly not all traits blended eg: Blue eyes X dark eyes dark eyes (rather than dark blue eye
Lecture 3 Mendelian genetics
I. Dihybrid cross A. Cross
B. Punnett square
WG Wg wG wg C. Branch Diagram 1. for genotype: What's the probability of WWGG?
What's the probability of WwGg?
2. for phenotype:
What's the probability of round, green?
Lecture 4 Mitosis I. There are two general types of cells somatic and germ cells A. somatic cells B. germ cells C. chromosomes often come in "pairs", called homologues 1. 2. 3. 4. D. cells of given species have characteristic number of sets of chromosomes
meiosis reduces ploidy
Lecture 5 Meiosis I. A few important points about meiosis # cells produced A. cell division that reduces chromosome number by 1/2 2n four 1n cells
B. crossing over used to increase genetic diversity of gametes produc
Lecture 6 Sex linkage I. Xlinked inheritance A. Drosophila white gene behaves oddly
so why is this unusual?
B. Is white restricted to males?
C. Is it a new pattern of inheritance?
Lecture 7 Pedigree analysis I. Pedigree A. what is it? diagram of familial relationship and transmission of traits. B. how is it useful?
C. In general, genetic disorders are very rare. D. 4 primary patterns of inheritance 1. autosomal recessive 2. autos
blood protein HbA/HbA viable not sickled HbA made Lecture 8 Genetic analysis/Modifications to Mendelian ratios HbA/HbS I. Gene products may not act independently viable partly sickled A. pleiotropy both HbA & HbS eg. fly white gene HbS/HbS lethal all sick
Lecture 9 Modifications of Mendelian ratios (continued) I. Interactions between mutations in different genes can modify 9:3:3:1 phenotypic ratios A. Interactions between genes in different pathways 1. corn snake normal has orange and black (camouflaged) p
Lecture 10environmental effects I. General A. environmental refers to genetic or physical 1. genetic 2. physical B. Can be seen as altered penetrance of expressivity Why? II. Genetic constitution A. genetic makeup affects expression of traits 1. Often dif
Lecture 22 Maternal effect and epigenetic inheritance I. Maternal effect
A. snail shell coiling in Limnaea peregra
Drosophila development genes C. maternal effect genes: summary usually little or n
name:_ student ID:_ Genetics L311 exam 1 September 26, 2008 Directions: Please read each question carefully. Answer questions as concisely as possible. Excessively long answers, particularly if they include any inaccuracies, may result in deduction of poi
In study of the newly discovered deep sea blood sucker is a mutation that causes short fangs. How can you explain the results below? short fang female X long fang male short fang females X long fang males short fang females X long fang males short fang An