Final Lecture 26 Post Cannabis Debate + Wrap-up
What issues need to be considered regarding the legalization of pot?
A little learning is a dangerous thing; drink deep, or taste not the Pierian spring: there shallow draughts intoxicate the brain, and drin
Theories of opiate addiction:
Person becomes physically dependent on opiates, thus they must continue use in order
to avoid fear, distress and pain of withdrawal
Opiates relieve preexisting dysphoric or
Tobacco & Nicotine; Historical Issues, Addiction
Video: Heroin addict who had a severe infection on her arm. She had talked about how she got
a strange cut of heroin which caused hallucinations her hallucination was that the
Treatment of Opioid Dependence
Instead of maintaining people on long-acting opiates for withdrawal, we are shifting towards
giving them the same drug they are addicted to but in lower doses and frequencies.
Detox: People sub
Opium poppy: Grows in dry climates. Opium comes from poppy plant, papaver somniferum
(sleep-inducing poppy). This is not the same variety as the garden plant. Opium is difficult to
synthesize in the lab; most morphine
Pharmacology and Neurobiology of Opiates
Harms of opiates are singular.
Injections of heroin are done TID-QID depending on degree of tolerance and dependence.
Users inject in a lot of veins in the body, e.g. neck veins, wrist
Health Burden, Epidemiology and Historical Issues
Health burden can come from drug abuse and dependence, trauma related to alcohol (very
costly to society, and a prominent source of mortality), organ damage related to alcohol
Neurobiology and Genetics of Alcohol Dependence
All drugs of abuse increase dopamine in the brain, especially amphetamine (microdialysis).
The mesocorticolimbic DA neurons form a crucial drug-sensitive component of rewardrela
Sedative and Hypnotic Wrap-up
There is a strong heritability component of alcohol and drug dependence. Factors in
development of SUD: Physiology (e.g. alcohol metabolism, craving, reward, etc.), genetics,
behaviour (e.g. pers
Lecture 4 Alcohol contd; Absorption, Intoxication
Route of administration changes peak effect, bioavailability, rate of onset
Alcohol routes of administration:
AWOL (alcohol without liquid): Allows alcohol mist to be inhaled this all
Case of Mr. F: Withdrawal, physically dependent, self-medicating with Ativan to mask effects
of withdrawal, social/family activities affected, tried to reduce intake, continued use despite
negative consequences (criteria of substance abuse).
Lecture 17- Abuse Liability and Neurobiology of Nicotine
Key Concepts Health consequences of tobacco use Biphasic physiological and neurochemical effects of nicotine in the CNS and PNS Abuse liability of nicotine (Henningfield studies with IV self-admini
Lecture 18 Etiology and Treatment of Tobacco Dependence
Key Concepts LeFoll study on sensitization and conditioning Genetic factors in tobacco dependence Does smoking meet DSM-IV criteria for substance dependence? Why is it difficult to quit smoking? pha
Lecture 21 Neurobiology of Relapse
FILM Through a Blue Lens disinhibition via inhibition of GABA release relapse model in animals reinstatement Bossert et al., 2011 Nature Neuroscience theories of opiate addiction clinical issues - lethal
Lecture 24 Cannabis Neurobiology
medicinal use of cannabis (Reefer Madness 2 film) cannabinoid receptors (CB1, CB2) synthetic cannabinoid compounds (WIN 55-212-2, a
full CB1 agonist shown to be administered IV in rats, Fattore et al., 2001,